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Information on EC 2.1.1.103 - phosphoethanolamine N-methyltransferase
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EC Tree
2.1.1.103 phosphoethanolamine N-methyltransferaseIUBMB Comments
The enzyme may catalyse the transfer of two further methyl groups to the product.
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Word Map
- 2.1.1.103
- phosphatidylcholine
- phosphocholine
- choline
- phospholipid
- plasmodium
- falciparum
- malaria
- betaine
- s-adenosylhomocysteine
-
plant-like
-
osmoprotectant
- cdp-choline
-
s-adenosylmethionine-dependent
-
transmethylation
- medicine
-
halophyte
-
s-adenosyl-l-methionine-dependent
-
nematicide
- amodiaquine
- drug development
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
pfpmt, peamt, phosphoethanolamine n-methyltransferase, phosphoethanolamine methyltransferase, pmt-1, atnmt1, pmeamt, s-adenosyl-l-methionine:phosphoethanolamine n-methyltransferase, peamt1, phosphomethylethanolamine n-methyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
PEAMT
PEAMT1
Pfpmt
phosphodimethylethanolamine methyltransferase
-
-
-
-
phosphoethanolamine methyltransferase
phosphoethanolamine N-methyltransferase
phosphoethanolamine-N-methyltransferases
PMT
PMT1
PMT2
PVX_083045
additional information
PfPMT is a member of an unusual class of SAM-dependent methyltransferases
PMT1
-
isozyme PMT1 contains a methyltransferase domain in the N-terminal half of the protein
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
random sequential kinetic mechanism
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase
The enzyme may catalyse the transfer of two further methyl groups to the product.
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CAS REGISTRY NUMBER
COMMENTARY
145539-90-8
-
171040-79-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
ethanolamine phosphate + S-adenosyl-L-methionine
N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
S-adenosyl-L-methionine + N,N-dimethylethanolamine phosphate
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + phosphomonomethylethanolamine
S-adenosyl-L-methionine + phosphomonomethylethanolamine
S-adenosyl-L-homocysteine + phosphodimethylethanolamine
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
-
overall reaction
-
-
?
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
-
-
-
-
?
3 S-adenosyl-L-methionine + phosphoethanolamine
3 S-adenosyl-L-homocysteine + phosphocholine
overall reaction
-
-
?
ethanolamine phosphate + S-adenosyl-L-methionine
N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
ethanolamine phosphate + S-adenosyl-L-methionine
N-methylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine
choline phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
N-methylethanolamine phosphate + S-adenosyl-L-methionine
N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
?
S-adenosyl-L-methionine + 2-(methylamino)ethyl phosphate
S-adenosyl-L-homocysteine + 2-(dimethylamino)ethyl phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
main step in phosphocholine biosynthesis. Inhibition of phosphocholine biosynthesis in xpl1 mutants not only alters several root developmental traits but also induces cell death in root epidermal cells
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
first reaction of a pathway for phosphocholine biosynthesis. PMT-1 functions at a step before monomethylethanolamine enters the plant-like phosphobase methylation pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
Chlamydomonas applanata NIES-2202
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
Chlamydomonas asymmetrica NIES-2207
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
the enzyme plays an important role in the biosynthetic pathway of phosphatidylcholine by providing the precursor phosphocholine via a three step S-adenosyl-L-methionine-dependent methylation of phosphoethanolamine. The enzyme function is directly coupled to the Kennedy pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
plays a critical role in the synthesis of phosphatidylcholine via the serine decarboxylase-phosphoethanolamine methyltransferase pathway
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
B3L8G9
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in production of free choline
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
-
?
S-adenosyl-L-methionine + ethanolamine phosphate
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
involved in synthesis of phosphocholine and phosphatidylcholine
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
reaction catalyzed by isozyme PMT2
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
reaction not catalyzed by phosphoethanolamine N-methyltransferase but by another enzyme
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
reaction not catalyzed by phosphoethanolamine N-methyltransferase but by another enzyme
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
poor substrate
-
?
S-adenosyl-L-methionine + phosphodimethylethanolamine
S-adenosyl-L-homocysteine + phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
first step in the PEAMTpathway, i.e. S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferases pathway, the enzyme pmt-1 is required for worm growth and development
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
-
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
Plasmodium falciparum PMT plays a critical role in the synthesis of phosphatidylcholine via a plant-like pathway involving serine decarboxylation and phosphoethanolamine methylation
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
the enzyme catalyzes one step of the the three-step methylation of phosphoethanolamine to phosphocholine
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
the phosphoethanolamine methyltransferase is a critical enzyme in the the plant-like serine decarboxylase-phosphoethanolamine methyltransferase, SDPM, pathway, and is downregulated at the transcriptional level as well as targeted for degradation by the proteasome in the presence of choline
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
amino acids Asp61, Gly83, and Asp128 play a critical role in enzyme activity. Asp-61 is located within the VLDIGSGLG motif I of PfPMT conserved in all PMTs, mutational analysis of PfPMT substrate binding, overview
-
-
?
S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + methylethanolamine phosphate
ZmPEAMT1 maybe involved in maize root development and stress resistance
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
Chlamydomonas applanata NIES-2202
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
Chlamydomonas asymmetrica NIES-2207
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + phosphomonomethylethanolamine
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reaction catalyzed by isozyme PMT1
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S-adenosyl-L-methionine + phosphoethanolamine
S-adenosyl-L-homocysteine + phosphomonomethylethanolamine
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S-adenosyl-L-methionine + phosphomonomethylethanolamine
S-adenosyl-L-homocysteine + phosphodimethylethanolamine
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reaction catalyzed by isozyme PMT2
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S-adenosyl-L-methionine + phosphomonomethylethanolamine
S-adenosyl-L-homocysteine + phosphodimethylethanolamine
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additional information
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PMEAMT cannot use phosphoethanolamine as a substrate, but assays using phosphomethylethanolamine as a substrate result in both phosphodimethylethanolamine and phosphocholine as products. PMEAMT is inhibited by the reaction products PCho and S-adenosyl-L-homocysteine
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additional information
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PMEAMT cannot use phosphoethanolamine as a substrate, but assays using phosphomethylethanolamine as a substrate result in both phosphodimethylethanolamine and phosphocholine as products. PMEAMT is inhibited by the reaction products PCho and S-adenosyl-L-homocysteine
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additional information
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the enzyme cannot use phosphoethanolamine as substrate
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additional information
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the enzyme cannot use phosphoethanolamine as substrate
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additional information
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the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies
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additional information
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the two NMT2 isoforms have the in vitro capacity to catalyze the triple methylation of phosphoethanolamine to produce choline phosphate, but with different efficiencies
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additional information
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the transcript levels of S-adenosyl-L-methionine synthetase are coregulated with those of phosphoethanolamine N-methyltransferase and choline monooxygenase to supply S-adenosyl-L-methionine for betaine synthesis in the leaves
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additional information
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no substrate: phosphomonomethylethanolamine
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additional information
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the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
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additional information
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Chlamydomonas applanata NIES-2202
no substrate: phosphomonomethylethanolamine
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additional information
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Chlamydomonas applanata NIES-2202
the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
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additional information
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no substrate: phosphomonomethylethanolamine
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additional information
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the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
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additional information
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Chlamydomonas asymmetrica NIES-2207
no substrate: phosphomonomethylethanolamine
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additional information
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Chlamydomonas asymmetrica NIES-2207
the enzyme shows no methyltransferase activity with phosphomonomethylethanolamine
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additional information
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no activity with phosphomethylethanolamine and phosphodimethylethanolamine
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additional information
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no activity with phosphomethylethanolamine and phosphodimethylethanolamine
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additional information
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isozyme PMT2 does not accept phosphoethanolamine as substrate
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additional information
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isoform PMT1 catalyzes the first step of the reactions, leading to the formation of phosphomonomethylethanolamine and the release of S-adenosylhomocysteine
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additional information
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isoform PMT1 catalyzes the first step of the reactions, leading to the formation of phosphomonomethylethanolamine and the release of S-adenosylhomocysteine
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additional information
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isoform PMT2 catalyzes the methylation of N-methylethanolamine phosphate to phosphodimethylethanolamine and subsequent methylation of phosphodimethylethanolamine to phosphocholine, releasing S-adenosyl-L-homocysteine at each methylation step
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additional information
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isoform PMT2 catalyzes the methylation of N-methylethanolamine phosphate to phosphodimethylethanolamine and subsequent methylation of phosphodimethylethanolamine to phosphocholine, releasing S-adenosyl-L-homocysteine at each methylation step
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additional information
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no activity with ethanolamine, methylethanolamine and dimethylethanolamine
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additional information
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no activity with phosphomethylethanolamine and phosphodimethylethanolamine
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additional information
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enzyme is directly coupled to the Kennedy pathway for the de novo synthesis of phosphatidylcholine
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additional information
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