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Information on EC 1.5.1.31 - berberine reductase

for references in articles please use BRENDA:EC1.5.1.31

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IUBMB Comments

Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.

The enzyme appears in viruses and cellular organisms
Reaction Schemes

Synonyms
(R)-canadine synthase, (S)-tetrahydroprotoberberine oxidase, STOX, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+
show the reaction diagram
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