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Information on EC 1.21.98.4 - PqqA peptide cyclase

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IUBMB Comments
This bacterial enzyme, which is a member of the radical SAM protein family, catalyses the formation of a C-C bond between C-4 of glutamate and C-3 of tyrosine residues of the PqqA protein (which are separated by three amino acid residues). This is the first enzymic step in the biosynthesis of the bacterial enzyme cofactor pyrroloquinoline quinone (PQQ). The reaction is dependent on the presence of a reductant (flavodoxin) and the accessory protein PqqD.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
pqqE, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a PqqA peptide + S-adenosyl-L-methionine = a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
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PATHWAY SOURCE
PATHWAYS
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