show all | hide all No of entries

Information on EC 1.17.99.10 - steroid C-25 hydroxylase

for references in articles please use BRENDA:EC1.17.99.10
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol. The enzyme can accept several substrates including vitamin D3. The enzyme contains a bis(guanylyl molybdopterin) cofactor, five [Fe-S] clusters, and one heme b. cf. EC 1.14.99.38, cholesterol 25-monooxygenase, an oxygen-requiring eukaryotic enzyme that catalyses a similar transformation.
Specify your search results
Select one or more organisms in this record: ?
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
+
=
25-hydroxycholest-4-en-3-one
+
+
+
=
25-hydroxycholest-4-en-3-one
+
Synonyms
C25 dehydrogenase, cholesterol C-25 dehydrogenase, D3 25-hydroxylase, s25dA1, s25dA1B3, s25dA1C3, S25DH, S25DH1, S25DH2, S25DH3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholest-4-en-3-one + acceptor + H2O = 25-hydroxycholest-4-en-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
Select items on the left to see more content.