show all | hide all No of entries

Information on EC 1.14.19.49 - tetracycline 7-halogenase

for references in articles please use BRENDA:EC1.14.19.49
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces aureofaciens, is a member of the flavin-dependent halogenase family. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH).
Specify your search results
Select one or more organisms in this record: ?
The enzyme appears in viruses and cellular organisms
Synonyms
ctcP, Cts4, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tetracycline + FADH2 + chloride + O2 + H+ = 7-chlorotetracycline + FAD + 2 H2O
show the reaction diagram
-
-
-
-
Select items on the left to see more content.