We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 1.14.14.74 - albendazole monooxygenase (hydroxylating) for references in articles please use BRENDA:EC1.14.14.74
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The expected taxonomic range for this enzyme is: Homo sapiens
Synonyms
CYP2J2,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CYP2J2
-
-
gene name
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
albendazole + [reduced NADPH-hemoprotein reductase] + O2 = hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
albendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
albendazole + [reduced NADPH-hemoprotein reductase] + O2
4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
astemizole + [reduced NADPH-hemoprotein reductase] + O2
hydroxyastemizole + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
ebastine + [reduced NADPH-hemoprotein reductase] + O2
hydroxyebastine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
terfenadine + [reduced NADPH-hemoprotein reductase] + O2
terfenadine alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
albendazole + [reduced NADPH-hemoprotein reductase] + O2
4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
P51589
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.004 - 0.0111
hydroxyebastine
-
0.0238 - 0.0472
telmisartan
0.00015 - 0.00427
terfenadone
-
0.00195
danazol
Homo sapiens
-
substrate ebastine, liver microsome, pH 7.4, 37°C
0.00214
danazol
Homo sapiens
-
substrate terfenadine, liver microsome, pH 7.4, 37°C
0.0138
danazol
Homo sapiens
-
substrate albendazole, liver microsome, pH 7.4, 37°C
0.0183
danazol
Homo sapiens
-
substrate astemizole, liver microsome, pH 7.4, 37°C
0.004
hydroxyebastine
Homo sapiens
-
substrate terfenadine, liver microsome, pH 7.4, 37°C
-
0.00928
hydroxyebastine
Homo sapiens
-
substrate astemizole, liver microsome, pH 7.4, 37°C
-
0.0111
hydroxyebastine
Homo sapiens
-
substrate albendazole, liver microsome, pH 7.4, 37°C
-
0.0238
telmisartan
Homo sapiens
-
substrate terfenadine, liver microsome, pH 7.4, 37°C
0.0472
telmisartan
Homo sapiens
-
substrate albendazole, liver microsome, pH 7.4, 37°C
0.00015
terfenadone
Homo sapiens
-
substrate astemizole, liver microsome, pH 7.4, 37°C
-
0.00031
terfenadone
Homo sapiens
-
substrate albendazole, liver microsome, pH 7.4, 37°C
-
0.0021
terfenadone
Homo sapiens
-
substrate terfenadine, liver microsome, pH 7.4, 37°C
-
0.00427
terfenadone
Homo sapiens
-
substrate ebastine, liver microsome, pH 7.4, 37°C
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
UniProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
-
albendazole hydroxylation correlates with CYP2J2 activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CP2J2_HUMAN
502
2
57611
Swiss-Prot
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
G312R
-
natural genetic variant, almost complete loss of enzymatic activity. Loss of CO binding to the heme, molecular modelling predicts a spatial hindrance between heme and the bulky side chain of the R312 residue in G312R
P351L
-
natural genetic variant, activity similar to wild-type
additional information
-
identification of 12 genetic variations from 93 Korean subjects
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
coexpression with NADPH-cytochrome P450 reductase in Sf9 cells
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Wu, Z.; Lee, D.; Joo, J.; Shin, J.; Kang, W.; Oh, S.; Lee, D.; Lee, S.; Yea, S.; Lee, H.; Lee, T.; Liu, K.
CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems
Antimicrob. Agents Chemother.
57
5448-5456
2013
Homo sapiens (P51589)
brenda
Lee, E.; Kim, J.H.; Shon, J.C.; Wu, Z.; Kim, H.J.; Gim, M.; Lee, T.; Liu, K.H.
Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes
Drug Metab. Pharmacokinet.
33
159-163
2018
Homo sapiens (P51589)
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
1.14.14.74 albendazole monooxygenase (hydroxylating)
more
top
Information
