Information on EC 1.14.14.74 - albendazole monooxygenase (hydroxylating)

for references in articles please use BRENDA:EC1.14.14.74
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IUBMB Comments
CYP2J2 is a microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).
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The enzyme appears in viruses and cellular organisms
Synonyms
CYP2J2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
albendazole + [reduced NADPH-hemoprotein reductase] + O2 = hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
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