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Information on EC 1.1.3.5 - hexose oxidase
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1.1.3.5 hexose oxidaseIUBMB Comments
A copper glycoprotein. Also oxidizes D-galactose, D-mannose, maltose, lactose and cellobiose.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
hexose oxidase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Hox
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glucose + O2 = D-glucono-1,5-lactone + H2O2
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
D-hexose:oxygen 1-oxidoreductase
A copper glycoprotein. Also oxidizes D-galactose, D-mannose, maltose, lactose and cellobiose.
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CAS REGISTRY NUMBER
COMMENTARY
9028-75-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-galactose + O2
2-deoxy-D-galactono-1,5-lactone + H2O2
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6% of activity with D-glucose
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?
2-deoxy-D-galactose + O2
2-deoxy-D-galactono-1,5-lactone + H2O2
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6% of activity with D-glucose
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?
2-deoxy-D-glucose + O2
2-deoxy-D-glucono-1,5-lactone + H2O2
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8% of activity with D-glucose
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?
2-deoxy-D-glucose + O2
2-deoxy-D-glucono-1,5-lactone + H2O2
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8% of activity with D-glucose
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?
2-deoxy-D-glucose + O2
2-deoxy-D-glucono-1,5-lactone + H2O2
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?
2-deoxy-D-glucose + O2
2-deoxy-D-glucono-1,5-lactone + H2O2
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-
?
2-deoxy-D-glucose + O2
2-deoxy-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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32% of activity with D-glucose
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
Citrus vulgaris
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
cellobiose + O2
4-O-(beta-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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-
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?
D-2-glucosamine + O2
2-amino-D-glucono-1,5-lactone + H2O2
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?
D-galactose + O2
D-galactono-1,5-lactone + H2O2
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82% of activity with D-glucose
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?
D-galactose + O2
D-galactono-1,5-lactone + H2O2
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82% of activity with D-glucose
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?
D-glucose-6-phosphate + O2
D-glucono-1,5-lactone-6-phosphate + H2O2
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10% of activity with D-glucose
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?
D-glucose-6-phosphate + O2
D-glucono-1,5-lactone-6-phosphate + H2O2
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10% of activity with D-glucose
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?
D-mannose + O2
D-mannono-1,5-lactone + H2O2
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8% of activity with D-glucose
8% of activity with D-glucose
?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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22% of activity with D-glucose
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
Citrus vulgaris
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
lactose + O2
4-O-(beta-D-galactopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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40% of activity with D-glucose
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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40% of activity with D-glucose
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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-
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
Citrus vulgaris
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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-
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?
maltose + O2
4-O-(alpha-D-glucopyranosido)-D-glucono-1,5-lactone + H2O2
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?
additional information
?
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hexose oxidase transforms a number of mono- and oligosaccharides such as beta-D-glucose, D-galactose, xylose, arabinose, cellobiose, lactose, maltose, maltotriose and maltotetraose to corresponding lactones, concomitant with the formation of H2O2, which is used for improving of on rheological and bread making properties of flour, hexose oxidase is used separately in each corn bran-wheat flour formula with L-ascorbic acid at 75 mg/kg, glucose at 0.5% and vital gluten at 9.2%
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?
additional information
?
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ferrous oxidation-xylenol orange (FOX) assay
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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hexose oxidase transforms a number of mono- and oligosaccharides such as beta-D-glucose, D-galactose, xylose, arabinose, cellobiose, lactose, maltose, maltotriose and maltotetraose to corresponding lactones, concomitant with the formation of H2O2, which is used for improving of on rheological and bread making properties of flour, hexose oxidase is used separately in each corn bran-wheat flour formula with L-ascorbic acid at 75 mg/kg, glucose at 0.5% and vital gluten at 9.2%
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
FAD
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the enzyme possesses a single catalytic FAD center covalently bound through His 79 and Cys 138 residues with improved stability and cofactor integrity. The redox transformation of FAD during biocatalysis involves a 2e?/2H+ transfer reaction, which is essential for enzymatic activities of FAD-containing enzymes. The formal potential of FAD in HOX, immobilized onto graphite electrodes, estimated as a mean value of the anodic and cathodic peak potentials is less negative than that of free FAD adsorbed directly onto graphite electrodes. Consistent with that, in the presence of glucose, bioelectrocatalysis of glucose oxidation by HOX starts from potentials exceeding those of HOX's FAD
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cu2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
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enzyme seems to be activated by proteolytic cleavage of full length protein, remaining polypeptide chains are physically linked together
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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H2O2 producing activities in different algaeal species, and with different substrates, overview
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE