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Information on EC 1.1.1.362 - aklaviketone reductase and Organism(s) Streptomyces sp. and UniProt Accession Q53882

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IUBMB Comments
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
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This record set is specific for:
Streptomyces sp.
UNIPROT: Q53882
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The taxonomic range for the selected organisms is: Streptomyces sp.
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
aklaviketone reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
aklavinone:NADP+ oxidoreductase
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
7-oxodaunomycinone + NADPH + H+
daunomycinone + NADP+
show the reaction diagram
-
-
-
?
aklaviketone + NADPH + H+
aklavinone + NADP+
show the reaction diagram
maggiemycin + NADPH + H+
epsilon-rhodomycinone + NADP+
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aklaviketone + NADPH + H+
aklavinone + NADP+
show the reaction diagram
the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
activity with NADH is 7% of the activity with NADPH
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25632
x * 25632, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 25632, calculated from sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzes the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dickens, M.L.; Ye, J.; Strohl, W.R.
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5
J. Bacteriol.
178
3384-3388
1996
Streptomyces sp. (Q53882)
Manually annotated by BRENDA team