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Enzyme Nomenclature
Information on EC 1.1.1.341 - CDP-abequose synthase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.1.1.341
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RECOMMENDED NAME
GeneOntology No.
CDP-abequose synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CDP-alpha-D-abequose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
CDP-alpa-D-abequose:NADP+ 4-oxidoreductase
Isolated from Yersinia pseudotuberculosis [1,3] and Salmonella enterica [1,2].
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
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enzyme is involved in synthesis of abequose, a constituent of the O-antigen of Salmonella B group strains
physiological function
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enzyme catalyzes the last step in synthesis of CDP-abequose from CPD-glucose. The 3,6-dideoxyhexose biosynthetic genes are clustered and relatively conserved throughout all four serogroups of Yersinia tuberculosis
physiological function
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insertion of the gene rfbJ encoding abequose synthase into a suicide vector and integration into the rfb clusters of wild-type Salmonella typhi Vi-positive strain ISP 1820, Salmonella typhi Vi-negative strain H400, and a double aro mutant of Salmonella typhi ISP 1820, strain CVD 906. Strains carrying the vector express the O4 antigen in place of the O9 antigen in the lipopolysaccharide molecule. Results suggest that the development of the 0-antigen serotype diversity of Salmonella is probably the result of both sequence divergence and recombination between heterologous rfb sequences. In addition, the results support the hypothesis that the chemical composition of the Salmonella 0-antigen influences the interaction of individual serotypes with complement
physiological function
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insertion of the gene rfbJ encoding abequose synthase into a suicide vector and integration into the rfb clusters of wild-type Salmonella typhi Vi-positive strain ISP 1820, Salmonella typhi Vi-negative strain H400, and a double aro mutant of Salmonella typhi ISP 1820, strain CVD 906. Strains carrying the vector express the O4 antigen in place of the O9 antigen in the lipopolysaccharide molecule. Results suggest that the development of the 0-antigen serotype diversity of Salmonella is probably the result of both sequence divergence and recombination between heterologous rfb sequences. In addition, the results support the hypothesis that the chemical composition of the Salmonella 0-antigen influences the interaction of individual serotypes with complement
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
33000
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x * 33000, SDS-PAGE, x * 34106, calculated
34106
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x * 33000, SDS-PAGE, x * 34106, calculated
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
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x * 33000, SDS-PAGE, x * 34106, calculated
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
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selection and use of primers to target defined regions of the abequose and paratose synthase genes responsible for biosynthesis of the oligosaccharide repeating units of the 0-antigenic lipopolysaccharide, in order to differentiate Salmonella serogroups. In a polymerase chain reaction assay utilizing these rjb-specific primers, all of the 40 salmonellae belonging to serogroups B, C2, and D plus A could accurately be identified among a total of 123 clinical isolates tested. No false-positive reactions were detected
medicine
medicine
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insertion of the gene rfbJ encoding abequose synthase into a suicide vector and integration into the rfb clusters of wild-type Salmonella typhi Vi-positive strain ISP 1820, Salmonella typhi Vi-negative strain H400, and a double aro mutant of Salmonella typhi ISP 1820, strain CVD 906. Strains carrying the vector express the O4 antigen in place of the O9 antigen in the lipopolysaccharide molecule. Results support the hypothesis that the chemical composition of the Salmonella 0-antigen influences the interaction of individual serotypes with complement
medicine
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insertion of the gene rfbJ encoding abequose synthase into a suicide vector and integration into the rfb clusters of wild-type Salmonella typhi Vi-positive strain ISP 1820, Salmonella typhi Vi-negative strain H400, and a double aro mutant of Salmonella typhi ISP 1820, strain CVD 906. Strains carrying the vector express the O4 antigen in place of the O9 antigen in the lipopolysaccharide molecule. Results support the hypothesis that the chemical composition of the Salmonella 0-antigen influences the interaction of individual serotypes with complement
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.341)
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