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Information on EC 1.1.1.288 - xanthoxin dehydrogenase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9C826
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1.1.1.288 xanthoxin dehydrogenaseIUBMB Comments
Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate . Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress .
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
wilty, xanthoxin dehydrogenase, aba deficient 2, os03g0810800, short-chain dehydrogenase/reductase1, glucose insensitive 1, 
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topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SDR1
SYSTEMATIC NAME
IUBMB Comments
xanthoxin:NAD+ oxidoreductase
Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3].
CAS REGISTRY NUMBER
COMMENTARY
129204-37-1
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
-
enzyme is involved abscisic acid biosynthesis
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
-
enzyme is involved in abscisic acid synthesis
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
-
last step in abscisic acid biosynthetic pathway, constitutively expressed, not upregulated in response to osmotic stress
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
multistep conversion
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
different mutants: mutations in genes involved in the ethylene signal transduction pathway and a mutation at the start of exon 2
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
-
enzyme is involved abscisic acid biosynthesis
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
-
enzyme is involved in abscisic acid synthesis
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
-
last step in abscisic acid biosynthetic pathway, constitutively expressed, not upregulated in response to osmotic stress
-
-
?
xanthoxin + NAD+
abscisic aldehyde + NADH + H+
multistep conversion
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
2.1fold reduced expression in Arabidopsis thaliana mutant aba2 with a mutation at the the start of exon 2
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
additional information
homologous AtSDR3 and AtABA2 have different spatial and temporal expression patterns
additional information
-
homologous AtSDR3 and AtABA2 have different spatial and temporal expression patterns
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
the aba2 mutant displays less seed dormancy, glucose insensitivity, small plat size, early flowering, and wiltness, no complementation by expression of AtSDR3, enotype, overview
additional information
additional information
comparative expression analysis of three AtSDR genes and their amino acid sequence alignment, overview
additional information
-
comparative expression analysis of three AtSDR genes and their amino acid sequence alignment, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ABA2_ARATH
285
0
30272
Swiss-Prot
other Location (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
generation of aba2 mutants. The pABA2::SDR3 transgene fails to complement the aba2 mutant phenotype, and transgenic plants show the same levels of ABA as the aba2 mutants, phenotype, overview
additional information
-
generation of aba2 mutants. The pABA2::SDR3 transgene fails to complement the aba2 mutant phenotype, and transgenic plants show the same levels of ABA as the aba2 mutants, phenotype, overview
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ABA2, encodes a short-chain dehydrogenase/reductase1 (SDR1) that catalyzes the multistep conversion of xanthoxin to abscisic aldehyde during abscisic acid biosynthesis in Arabidopsis thalian, genotyping
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Taylor, I.B.; Burbidge, A.; Thompson, A.J.
Control of abscisic acid synthesis
J. Exp. Bot.
51
1563-1574
2000
Arabidopsis thaliana
Gonzalez-Guzman, M.; Apostolova, N.; Belles, J.M.; Barrero, J.M.; Piqueras, P.; Ponce, M.R.; Micol, J.L.; Serrano, R.; Rodriguez, P.L.
The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde
Plant Cell
14
1833-1846
2002
Arabidopsis thaliana
Cheng, W.H.; Endo, A.; Zhou, L.; Penney, J.; Chen, H.C.; Arroyo, A.; Leon, P.; Nambara, E.; Asami, T.; Seo, M.; Koshiba, T.; Sheen, J.
A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions
Plant Cell
14
2723-2743
2002
Arabidopsis thaliana
Schwartz, S.H.; Leon-Kloosterziel, K.M.; Koornneef, M.; Zeevaart, J.A.
Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana
Plant Physiol.
114
161-166
1997
Arabidopsis thaliana
Cheng, W.H.; Chiang, M.H.; Hwang, S.G.; Lin, P.C.
Antagonism between abscisic acid and ethylene in Arabidopsis acts in parallel with the reciprocal regulation of their metabolism and signaling pathways
Plant Mol. Biol.
71
61-80
2009
Arabidopsis thaliana (Q9C826)
Hwang, S.G.; Lin, N.C.; Hsiao, Y.Y.; Kuo, C.H.; Chang, P.F.; Deng, W.L.; Chiang, M.H.; Shen, H.L.; Chen, C.Y.; Cheng, W.H.
The Arabidopsis short-chain dehydrogenase/reductase 3, an abscisic acid deficient 2 homolog, is involved in plant defense responses but not in ABA biosynthesis
Plant Physiol. Biochem.
51
63-73
2012
Arabidopsis thaliana (Q9SCU0), Arabidopsis thaliana
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