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The enzyme appears in viruses and cellular organisms
Synonyms
16alpha-hydroxy steroid dehydrogenase,
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16alpha-hydroxy steroid dehydrogenase
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a 16alpha-hydroxysteroid + NAD(P)+ = a 16-oxosteroid + NAD(P)H + H+
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16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase
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16-ketotestosterone + NAD(P)H
16alpha-hydroxytestosterone + NAD(P)+
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16-oxo-17beta-estradiol + NADH + H+
16alpha-hydroxy-17beta-estradiol + NAD+
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17alpha-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17alpha-estradiol + NAD(P)+
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best substrate tested, changing configuration or oxidation state of the neighboring oxygen substituent at C-17 increases the rate of reduction
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17beta-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17beta-estradiol + NAD(P)+
3-hydroxy-estra-1,3,5(10)-triene-16,17-dione + NAD(P)H + H+
3,16alpha-dihydroxy-estra-1,3,5(10)-triene-17-one + NAD(P)+
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3beta,17beta-dihydroxy-androst-5-en-16-one + NAD(P)H
3beta,16alpha,17beta-trihydroxyandrost-5-ene + NAD(P)+
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low activity
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estra-1,3,5(10)-triene-3,16beta,17beta-triol + NAD(P)+
estra-1,3,5(10)-triene-3,17beta-diol-16-one + NAD(P)H
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estra-1,3,5(10)triene-3,17-beta-diol-16-one + NAD(P)H
estra-1,3,5(10)triene-3,16alpha,17-triol + NAD(P)+
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low activity
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17beta-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17beta-estradiol + NAD(P)+
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17beta-estradiol-16-one + NAD(P)H
16alpha-hydroxy-17beta-estradiol + NAD(P)+
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NADH
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40% lower reaction rate than NADPH
NADPH
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40% greater reaction rate than NADH
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1,10-phenanthroline
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complete inhibition at 0.1 mM
2,2'-bipyridine
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19% inhibition at 0.1 mM
2-Iodoacetamide
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86% inhibition at 1 mM
8-hydroxy-5-quinolinesulfonate
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89% inhibition at 1 mM
Ag+
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78% inhibition at 0.01 mM
Cu2+
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98% inhibition at 0.01 mM
EDTA
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97% inhibition at 0.01 mM
N-ethylmaleimide
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94% inhibition at 0.1 mM
o-Iodosobenzoate
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complete inhibition at 0.1 mM
p-hydroxymercuribenzoate
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complete inhibition at 0.01 mM
Zn2+
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84% inhibition at 0.1 mM
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0.28
16-ketotestosterone
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0.07
17alpha-estradiol-16-one
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0.089
17beta-estradiol-16-one
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inducible by estrogen administration
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extremely unstable, glycerol partially protects against inactivation
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Meigs, R.A.; Ryan, K.J.
16alpha-Hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties
J. Biol. Chem.
241
4011-4015
1966
Rattus sp.
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Preumont, P.; Smuk, M.
16-Dehydrogenase in human placenta
Acta Endocrinol.
78
760-765
1975
Homo sapiens
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1.1.1.147 16alpha-hydroxysteroid dehydrogenase
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