Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase and Organism(s) Mesocricetus auratus and UniProt Accession Q6R0J2

for references in articles please use BRENDA:EC1.1.1.146
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mesocricetus auratus
UNIPROT: Q6R0J2 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mesocricetus auratus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
11beta-hsd1, 11beta-hsd2, hsd11b2, hsd11b1, 11beta-hydroxysteroid dehydrogenase, 11beta-hsd, 11beta-hydroxysteroid dehydrogenase type 1, beta-hydroxysteroid dehydrogenase, 11betahsd2, 11betahsd1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11beta-hydroxysteroid dehydrogenase type 1
-
11-beta-HSD1
-
-
-
-
11-beta-HSD2
-
-
-
-
11-DH
-
-
-
-
11-DH2
-
-
-
-
11beta-HSD1A
-
-
-
-
11beta-hydroxy steroid dehydrogenase
-
-
-
-
beta-hydroxysteroid dehydrogenase
-
-
-
-
corticosteroid 11-reductase
-
-
-
-
corticosteroid 11beta-dehydrogenase
-
-
-
-
dehydrogenase, 11beta-hydroxy steroid
-
-
-
-
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9041-46-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 7-oxocholesterol + 2 NADPH + 2 H+
7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+
show the reaction diagram
-
40% and 60%, respectively, in lysates of HEK-293 cells and intact HEK-293 cells expressing 11beta-HSD1
-
r
7alpha-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
show the reaction diagram
in lysates of HEK-293 cells expressing 11beta-HSD1, no oxidation in intact HEK293 cells expressing 11beta-HSD1
-
-
r
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
show the reaction diagram
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
show the reaction diagram
-
-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
show the reaction diagram
-
-
-
r
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
show the reaction diagram
-
-
-
r
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-hydroxyflavanone
0.2 mM, more than 90% inhibition of 7-oxocholesterol reduction in liver homogenates
carbenoxolone
0.01 mM, more than 90% inhibition of 7-oxocholesterol reduction in liver homogenates
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004
11-Dehydrocorticosterone
37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1
0.00038
7-oxocholesterol
37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1
0.00049
7alpha-hydroxycholesterol
37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1
0.00073
7beta-hydroxycholesterol
37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1
0.0032
corticosterone
37°C, pH 7.4, in HEK-293 lysates expressing 11beta-HSD1
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DHI1_MESAU
292
1
32305
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in HEK-293 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schweizer, R.A.; Zurcher, M.; Balazs, Z.; Dick, B.; Odermatt, A.
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme
J. Biol. Chem.
279
18415-18424
2004
Homo sapiens, Rattus norvegicus, Mesocricetus auratus (Q6R0J2)
Manually annotated by BRENDA team