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Information on EC 1.1.1.146 - 11beta-hydroxysteroid dehydrogenase and Organism(s) Ovis aries and UniProt Accession P50168

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Ovis aries
UNIPROT: P50168 not found.
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The taxonomic range for the selected organisms is: Ovis aries
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
11beta-hsd1, 11beta-hsd2, hsd11b2, hsd11b1, 11beta-hydroxysteroid dehydrogenase, 11beta-hsd, 11beta-hydroxysteroid dehydrogenase type 1, 11betahsd2, beta-hydroxysteroid dehydrogenase, 11betahsd1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Hsd11B2
isoform
hydroxysteroid (11-beta) dehydrogenase
-
11-beta-HSD1
-
-
-
-
11-beta-HSD2
-
-
-
-
11-DH
-
-
-
-
11-DH2
-
-
-
-
11beta-HSD1
-
-
11beta-HSD1A
-
-
-
-
11beta-hydroxy steroid dehydrogenase
-
-
-
-
11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase isoforms 1
-
-
beta-hydroxysteroid dehydrogenase
-
-
-
-
corticosteroid 11-reductase
-
-
-
-
corticosteroid 11beta-dehydrogenase
-
-
-
-
dehydrogenase, 11beta-hydroxy steroid
-
-
-
-
HSD11B1
isoform
hydroxysteroid (11-beta) dehydrogenase
-
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
9041-46-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cortisol + NADP+
cortisone + NADPH + H+
show the reaction diagram
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
show the reaction diagram
-
-
-
r
cortisol + NADP+
cortisone + NADPH + H+
show the reaction diagram
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
show the reaction diagram
-
-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cortisol + NADP+
cortisone + NADPH + H+
show the reaction diagram
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
show the reaction diagram
-
-
-
r
cortisol + NADP+
cortisone + NADPH + H+
show the reaction diagram
-
-
-
r
cortisone + NADPH + H+
cortisol + NADP+
show the reaction diagram
-
-
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
morpholino antisense oligonucleotide
about 50% inhibition at 0.002 mM
-
11-dehydrocortisterone
-
-
11-oxo-3beta,5alpha-tetrathydrotestosterone
-
-
11-oxo-allopregnanolone
-
-
11-oxo-progesterone
-
-
11-oxo-testosterone
-
-
11beta-hydroxy-allopregnanolone
-
-
11beta-hydroxyandrostanediol
-
-
11beta-hydroxyandrostenedione
-
-
11beta-hydroxyprogesterone
-
-
11beta-hydroxytestosterone
-
-
3alpha,5alpha-tetrahydro-dehydrocortisterone
-
-
3alpha,5alpha-tetrahydroaldosterone
-
-
3alpha,5alpha-tetrahydrocorticosterone
-
-
3alpha,5alpha-tetrahydrocortisol
-
-
5alpha-dihydrocorticosterone
-
-
morpholino antisense oligonucleotide
about 50% inhibition at 0.002 mM
-
additional information
-
steroid hormones, adrenocorticosteroid derivatives, progesteron and androgen steroid hormones, with 5alpha-ring A reduced-configuration selectively inhibit isozyme 11beta-HSD2, while 5beta-derivatives are inactive
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00047
11-dehydrocortisterone
Ovis aries
-
pH 8.4, 37°C
0.008
11-oxo-3beta,5alpha-tetrathydrotestosterone
Ovis aries
-
pH 8.4, 37°C
0.0015
11-oxo-allopregnanolone
Ovis aries
-
pH 8.4, 37°C
0.0004
11-oxo-progesterone
Ovis aries
-
pH 8.4, 37°C
0.00135
11-oxo-testosterone
Ovis aries
-
pH 8.4, 37°C
0.00012
11beta-hydroxy-allopregnanolone
Ovis aries
-
pH 8.4, 37°C
0.0045
11beta-hydroxyandrostanediol
Ovis aries
-
pH 8.4, 37°C
0.0078
11beta-hydroxyandrostenedione
Ovis aries
-
pH 8.4, 37°C
0.00005
11beta-hydroxyprogesterone
Ovis aries
-
pH 8.4, 37°C
0.00035
11beta-hydroxytestosterone
Ovis aries
-
pH 8.4, 37°C
0.0008
3alpha,5alpha-tetrahydro-dehydrocortisterone
Ovis aries
-
pH 8.4, 37°C
0.0005
3alpha,5alpha-tetrahydroaldosterone
Ovis aries
-
pH 8.4, 37°C
0.00026
3alpha,5alpha-tetrahydrocorticosterone
Ovis aries
-
pH 8.4, 37°C
0.008
3alpha,5alpha-tetrahydrocortisol
Ovis aries
-
pH 8.4, 37°C
0.00015
5alpha-dihydrocorticosterone
Ovis aries
-
pH 8.4, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
of animals that received betamethasone as a fetus, or whose mothers received betamethasone during pregnancy. Adult animals demonstrate increased mineralocorticoid and 11beta-HSD2 mRNA levels
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DHI2_SHEEP
427
0
46669
Swiss-Prot
other Location (Reliability: 2)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
exposure of fetus to high levels of synthetic glucocorticoid may have long-lasting effects on the hippocampal expression of hypothalamic-pituitary-adrenal-related genes into adulthood
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Latif, S.A.; Pardo, H.A.; Hardy, M.P.; Morris, D.J.
Endogenous selective inhibitors of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin
Mol. Cell. Endocrinol.
243
43-50
2005
Ovis aries, Homo sapiens
Manually annotated by BRENDA team
Sloboda, D.M.; Moss, T.J.; Li, S.; Matthews, S.G.; Challis, J.R.; Newnham, J.P.
Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure
J. Endocrinol.
197
213-220
2008
Ovis aries
Manually annotated by BRENDA team
Brooks, K.; Burns, G.; Spencer, T.E.
Biological roles of hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), HSD11B2, and glucocorticoid receptor (NR3C1) in sheep conceptus elongation
Biol. Reprod.
93
38
2015
Ovis aries (P50168), Ovis aries (P51975), Ovis aries
Manually annotated by BRENDA team