2.6.1.64: glutamine-phenylpyruvate transaminase

This is an abbreviated version!
For detailed information about glutamine-phenylpyruvate transaminase, go to the full flat file.

Reaction

Synonyms

cysteine conjugate beta-lyase/glutamine transaminase K, EC 2.6.1.14, EC 2.6.1.15, EC 2.6.1.7, Gln/phenylpyruvate transaminase, glutamic-oxaloacetic transaminase, glutamine transaminase K, glutamine transaminase L, glutamine transaminase-K, glutamine-phenylpyruvate aminotransferase, glutamine/phenylpyruvate transaminase, GOT1, GTK, histidine pyruvate aminotransferase isoenzyme 2, KAT/GTK, kynurenine aminotransferase/glutamine transaminase K

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.64 glutamine-phenylpyruvate transaminase

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Results	in table
24	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
1	Disease/ Diagnostics
2	Expression
1	General Information
3	General Stability
15	Inhibitors
56	KM Value [mM]
28	Localization
20	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
876	Organism
24	PDB ID
5	pH Optimum
1	pH Range
1	pI Value
13	Purification (Commentary)
1	Reaction
1	Reaction Type
35	Reference
73	Source Tissue
10	Specific Activity [micromol/min/mg]
2	Storage Stability
198	Substrates and Products (Substrate)
13	Subunits
39	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
21	Turnover Number [1/s]

Expression

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Expression on EC 2.6.1.64 - glutamine-phenylpyruvate transaminase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

GOT1 expression level is reduced in TAZ/YAP siRNA knockout cells. The inhibition of transamination preferentially suppresses those breast cancer cells that express high levels of TAZ/YAP (e.g. MDA-MB-231 and HCC38 cells ), not TAZ/YAP-low-level expressing cell lines (e.g. BT474 and HMT-3522 S1)

Homo sapiens

P17174

759123

transcriptional regulators TAZ and YAP (TAZ/YAP) promote glutamine dependence in breast cancer cells and activate the expression of glutamine-utilizing transaminases to support cell growth. TAZ/YAP induce glutamic-oxaloacetic transaminase (GOT1) and phosphoserine aminotransferase (PSAT1) expression. TAZ and YAP are required for glutamine-utilizing transaminase expression in breast cancer cells

Homo sapiens

P17174

759123