2.1.1.71: phosphatidyl-N-methylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidyl-N-methylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.71
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2.1.1.71
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phosphatidylcholine
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transmethylation
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n2-guanine
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phosphatidyl-n,n-dimethylethanolamine
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corrinoid
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s-adenosyl-l-methyl-3hmethionine
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3hmethyl
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medicine
- 2.1.1.71
- phosphatidylcholine
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transmethylation
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n2-guanine
- phosphatidyl-n,n-dimethylethanolamine
- corrinoid
-
s-adenosyl-l-methyl-3hmethionine
-
3hmethyl
- medicine
Reaction
Synonyms
class I PLMT, methyltransferase II, PE N-MTase, PEMT-L, PEMT-S, phosphatidyl-N-methylethanolamine methyltransferase, phosphatidyl-N-monomethylethanolamine methyltransferase, phosphatidylethanolamine methyltransferase I, phosphatidylethanolamine N-methyltransferase, phosphatidylmonomethylethanolamine methyltransferase, phospholipid methyltransferase, phospholipid N-methyltransferase, PLMT
ECTree
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General Information
General Information on EC 2.1.1.71 - phosphatidyl-N-methylethanolamine N-methyltransferase
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metabolism
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PEMT-L and PEMT-S expression increase the cellular phosphatidylcholine content, whereas the phosphatidylethanolamine content is decreased by PEMT-S expression, but is hardly affected by PEMT-L expression. The cellular content of phosphatidylserine is also reduced by the expression of PEMT-L or PEMT-S
physiological function
although the accumulation of the PLMT substrates phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine is considerably elevated in the plmt knock-out line, phosphatidylcholine levels remain normal, and no obvious differences are observed in plant morphology or development under standard growth conditions
physiological function
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PEMT-L and PEMT-S expression promote the proliferation of HEK-293 cells