2.1.1.290: tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase

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For detailed information about tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase, go to the full flat file.

Reaction

7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe

7-[(3S)-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe

Synonyms

tRNA yW-synthesizing enzyme 4, tRNA-yW synthesizing enzyme-4, tRNA-yW synthesizing protein 4, TYW4, YOL141w

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.290 tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase

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Results	in table
4482	AA Sequence
1	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
2	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
82	Organism
1	Pathway
2	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reaction Type
7	Reference
10	Substrates and Products (Substrate)
4	Subunits
16	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.290 - tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase

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S-adenosyl-L-methionine:tRNAPhe {7-[(3S)-3-amino-3-carboxypropyl]wyosine37-O}-methyltransferase

The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase [2].