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1.11.1.25: glutaredoxin-dependent peroxiredoxin

This is an abbreviated version!
For detailed information about glutaredoxin-dependent peroxiredoxin, go to the full flat file.

Word Map on EC 1.11.1.25

Reaction

glutaredoxin
+
ROOH
=
glutaredoxin disulfide
 +
H2O
 +
ROH

Synonyms

EC 1.11.1.15, glutaredoxin-dependent peroxidase, Grx3/GSH-dependent peroxidase, peroxiredoxin-glutaredoxin, Prx1, Prx3, Prx5-Grx, PRXIIB, TM0780, TmPrxBCP, TmPrxNtr, TM_0386, type II peroxiredoxin

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.25 glutaredoxin-dependent peroxiredoxin

Engineering

Engineering on EC 1.11.1.25 - glutaredoxin-dependent peroxiredoxin

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C185A
K230A
the mutant shows impaired binding to plasminogen
K230A/K244A
the mutant shows impaired binding to plasminogen
K244A
the mutant shows slightly impaired binding to plasminogen
C185A
K230A
-
the mutant shows impaired binding to plasminogen
-
K230A/K244A
-
the mutant shows impaired binding to plasminogen
-
K244A
-
the mutant shows slightly impaired binding to plasminogen
-
C51A
mutation abolishes catalysis
C76A
mutant enzyme retains about 25% of the wild type peroxiredoxin activity
V152C
the mutant enzyme is inactive with glutaredoxin as a proton donor, is catalytically active with thioredoxin
R129Q
-
inactive with H2O2 or tert-butyl hydroperoxide, catalyzes degradation of cumene hydroperoxide with low efficiency
T48V
-
inactive with H2O2 or tert-butyl hydroperoxide, catalyzes degradation of cumene hydroperoxide with low efficiency