1.1.1.200: aldose-6-phosphate reductase (NADPH)
This is an abbreviated version!
For detailed information about aldose-6-phosphate reductase (NADPH), go to the full flat file.
Word Map on EC 1.1.1.200
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1.1.1.200
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sorbitol
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apple
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domestica
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malus
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starch
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rosaceae
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peach
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adp-glucose
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borkh
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2.4.1.14
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hexokinase
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sink
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invertase
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greensleeves
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fructokinase
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pyrophosphorylase
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prunus
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2.7.7.27
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gala
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sugar-phosphates
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aldo-keto
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sink-source
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glucitol
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persica
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mixed-type
- 1.1.1.200
- sorbitol
- apple
- domestica
- malus
- starch
- rosaceae
- peach
- adp-glucose
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borkh
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2.4.1.14
- hexokinase
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sink
- invertase
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greensleeves
- fructokinase
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pyrophosphorylase
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prunus
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2.7.7.27
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gala
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sugar-phosphates
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aldo-keto
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sink-source
- glucitol
- persica
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mixed-type
Reaction
Synonyms
A6PR, A6PR1, A6PR2, A6PRase, Ald6PRase, alditol 6-phosphate:NADP 1-oxidoreductase, aldose-6-P reductase, aldose-6-phosphate reductase, aldose-6-phosphate reductase [NADPH], NADP-S6PDH, NADPH-dependent aldose 6-phosphate reductase, reductase, aldose 6-phosphate, S6PDH, sorbitol-6-phosphate dehydrogenase
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Substrates Products
Substrates Products on EC 1.1.1.200 - aldose-6-phosphate reductase (NADPH)
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REACTION DIAGRAM
D-galactose 6-phosphate + NADPH
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reduced at a higher rate than D-glucose 6-phosphate
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D-glucose 6-phosphate + NADPH + H+
D-glucitol-6-phosphate + NADP+
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D-sorbitol 6-phosphate + NADP+
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D-glucose 6-phosphate + NADPH + H+
D-sorbitol 6-phosphate + NADP+
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r
D-glucose 6-phosphate + NADPH + H+
D-sorbitol 6-phosphate + NADP+
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D-sorbitol 6-phosphate + NADP+
D-glucose 6-phosphate + NADPH + H+
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r
D-sorbitol 6-phosphate + NADP+
D-glucose 6-phosphate + NADPH + H+
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r
D-sorbitol 6-phosphate + NADP+
D-glucose 6-phosphate + NADPH + H+
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not: D-glucose 1-phosphate, D-fructose 6-phosphate, D-ribose 5-phosphate, D-glucose, sorbitol
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additional information
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when sorbitol synthesis is decreased by antisense inhibition of A6PR expression, cytosolic FBPase activity in vivo is down-regulated to reduce the carbon flux to cytosol and starch synthesis in the chloroplast is consequently upregulated
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additional information
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effects of mild and severe water stress on the sorbitol metabolism in leaves, A6PR activity is increased in response to water stress, while sorbitol accumulates under mild to moderate stress but is decreased under severe stress in leaves, overview
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additional information
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both, the N- and the C-term tagged enzymes exhibit similar affinity toward substrates
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additional information
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both, the N- and the C-term tagged enzymes exhibit similar affinity toward substrates
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additional information
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effects of fruit removal on the carbon metabolism in leaves, the enzyme activity ins increased after fruit removal, although starch and sorbitol accumulate in the leaves, overview
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additional information
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almost no activity with mannose 6-phosphate or ribose 5-phosphate, no activity with NADH and NAD+
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additional information
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almost no activity with mannose 6-phosphate or ribose 5-phosphate, no activity with NADH and NAD+
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