EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.73 | C122S |
mutant of the serine proteinase domain |
652910 |
| 3.4.21.73 | E137A |
site-directed mutagenesis, introduction of the mutations F40Y or E137A into muPA(16-243) increased exposure of the N-terminus (Ile16) and resulted in large changes in the thermodynamic parameters for mupain-1-16 binding |
731301 |
| 3.4.21.73 | E301A |
site-directed mutagenesis |
651870 |
| 3.4.21.73 | E301D |
site-directed mutagenesis |
651870 |
| 3.4.21.73 | E301H |
site-directed mutagenesis |
651870 |
| 3.4.21.73 | F40Y |
site-directed mutagenesis, introduction of the mutations F40Y or E137A into muPA(16-243) increased exposure of the N-terminus (Ile16) and resulted in large changes in the thermodynamic parameters for mupain-1-16 binding |
731301 |
| 3.4.21.73 | H99Y |
site-directed mutagenesis, structure analysis with bound inhibitors |
731932 |
| 3.4.21.73 | H99Y |
site-directed mutagenesis, the mutation exchanges the human residue H99 for the murine equivalent Y99, rendering the mutant enzyme susceptible for inhibition by the murine peptide sequence mupain-1, overview |
683130 |
| 3.4.21.73 | H99Y/Q192K |
site-directed mutagenesis, the mutations exchanges the human residues for the murine equivalents, rendering the mutant enzyme susceptible for inhibition by the murine peptide sequence mupain-1, overview |
683130 |
| 3.4.21.73 | K300A |
site-directed mutagenesis |
651870 |
