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EC Number
Protein Variants
Commentary
Reference
3.1.6.14
C80A
inactive
704598
3.1.6.14
D186A
53% relative activity after 0.5 h and 92% relative activity after 5 h compared to the wild type enzyme
704598
3.1.6.14
D374A
inactive
704598
3.1.6.14
more
mutation of glutamine 390 to stop-codon causes Mucopolysaccharidosis type IIID
677855
3.1.6.14
more
silencing the expression of Sulf-1 by RNA interference restores the responses induced by FGF-1, which indicates that TNF-alpha-mediated induction of the sulfatase results in alterations of HS biological properties
761256
3.1.6.14
R102X
nonsense mutation
135594
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