EC Number   |
Protein Variants |
Reference |
|---|
   2.7.11.25 | A62D |
site-directed mutagenesis, no binding of Ste50 |
666069 |
| 2.7.11.25 | C433A |
completely abolishes its interaction with RhoA |
681764 |
| 2.7.11.25 | C441A |
site-directed mutagenesis, the mutant enzyme is not ubiquitinylated and thus shows a higher ERK activating activity |
665482 |
| 2.7.11.25 | D13A |
site-directed mutagenesis, the mutation of the conserved Asp13 of MEKK3 to Ala completely abolishes the binding between CCM2ct and MEKK3nt |
741446 |
| 2.7.11.25 | D169A |
site-directed mutagenesis, the kinase-dead mutation of TAO2-1 does not influence the ERK5 activation level |
665601 |
| 2.7.11.25 | D270A |
site-directed mutagenesis of COT30-397, inactive mutant |
663773 |
| 2.7.11.25 | DELTA321-340 |
practically identical to the wild type |
694158 |
| 2.7.11.25 | DELTA341-360 |
practically identical to the wild type |
694158 |
| 2.7.11.25 | DELTA361-380 |
practically identical to the wild type |
694158 |
| 2.7.11.25 | DELTA381-400 |
defective in osmotic induction of the 8xCRE-lacZ reporter, mutant is osmosensitive |
694158 |
