EC Number   |
General Information |
Reference |
|---|
   3.4.23.B19 | malfunction |
deletions involving the membrane anchor are lethal |
710052 |
| 3.4.23.B19 | malfunction |
disruption of the enzyme gene leads to a developmental arrest in the subsequent erythrocytic cycle |
755178 |
| 3.4.23.B19 | malfunction |
plasmepsin V inhibition blocks export of malaria proteins to human erythrocytes and inhibits parasite growth |
754874 |
| 3.4.23.B19 | metabolism |
the enzyme cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte |
754861 |
| 3.4.23.B19 | metabolism |
the enzyme is responsible for the cleavage of Plasmodium export element-tagged proteins destined for export outside of the host red blood cell |
754690 |
| 3.4.23.B19 | metabolism |
the enzyme is responsible for the cleavage of the Plasmodium export element (PEXEL) motif at the N-terminus of several hundreds of the exported proteins |
754669 |
| 3.4.23.B19 | physiological function |
plasmepsin V recognizes pentameric motif RxLxE/Q/D of exported proteins. Plasmepsin V cleavage reveals the export signal xE/Q/D at the N-terminus of cargo proteins. Plasmepsin V activity is essential and linked with other key export events |
718159 |
| 3.4.23.B19 | physiological function |
PM V is the enzyme that processes PEXEL containing proteins to send them on their way for export into the host cell |
710052 |
| 3.4.23.B19 | physiological function |
the enzyme is essential for the survival, development and virulence of the parasite in the erythrocyte |
755440 |
| 3.4.23.B19 | physiological function |
the enzyme processes proteins for export into the host erythrocyte and plays a crucial role in parasite virulence and survival |
754673 |
