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EC Number	General Information	Commentary	Reference
3.4.23.B11	more	the Pro-Pol polyprotein elements A and B are required for protease dimerization and activation, while the C-element is required for pol expression and splicing regulation	755371
3.4.23.B11	physiological function	the RNase H domain is essential for protease activity, but can functionally be substituted by RNase H domains of other retroviruses.The RNase H domain might be involved in the stabilization of the protease dimer, while the reverse transcriptase domain is essential for RNA dependent protease activation	731017

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Release 2023.1 (January 2023)