EC Number   |
General Information |
Reference |
|---|
   3.4.21.26 | malfunction |
depletion/inhibition of prolylcarboxypeptidase (PRCP)/prolylendopeptidase (PREP) suppresses rapamycin-induced activation of PI3K/AKT with consequent additive/synergistic cytotoxicity |
732142 |
| 3.4.21.26 | malfunction |
enzyme associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders |
710367 |
| 3.4.21.26 | malfunction |
enzyme inhibition induces calcium signaling via phospholipase c stimulation which further triggers mitochondrial mediated apoptosis in filarial parasites |
752673 |
| 3.4.21.26 | malfunction |
inhibition or knockdown of prolyl oligopeptidase leads to suppression of NB-1 cell growth, and the effect is accompanied by G0/G1 arrest |
717197 |
| 3.4.21.26 | malfunction |
involvement of enzyme in mechanisms of neoplastic processes suggested |
710533 |
| 3.4.21.26 | metabolism |
prolyl endopeptidase is involved in collagen breakdown |
717073 |
| 3.4.21.26 | metabolism |
prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from thymosin beta4, and it has autoregulatory effect in the first step |
717447 |
| 3.4.21.26 | more |
human PREP behaves identically to the porcine homologue, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV) |
755291 |
| 3.4.21.26 | physiological function |
cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase |
717073 |
| 3.4.21.26 | physiological function |
enzyme overexpression increases progesterone secretion, increases ERK1/2 phosphorylation and increases the expression of steroidogenic factor 1. The enzyme regulates progesterone secretion by stimulating the expression of CYP11A, 3beta-hydroxysteroid dehydrogenase, and steroidogenic acute regulatory protein in luteal cells |
754790 |
