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Literature summary for 3.4.21.26 extracted from

  • Xu, P.; Bao, R.; Zhang, Y.; Lu, E.; Feng, F.; Zhang, L.; Li, J.; Wang, J.; Tan, X.; Tang, M.; Hu, C.; Li, G.; Zhang, C.
    Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells (2019), Mol. Reprod. Dev., 86, 714-726 .
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
KYP-2047 selective inhibitor, i.e (2S)-1[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinylcarbonyl]-2-pyrrolidinecarbonitrile Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corpus luteum
-
 Mus musculus
-
luteal cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
PEP
-
 Mus musculus
POP
-
 Mus musculus
PREP
-
 Mus musculus

General Information

General Information Comment Organism
physiological function enzyme overexpression increases progesterone secretion, increases ERK1/2 phosphorylation and increases the expression of steroidogenic factor 1. The enzyme regulates progesterone secretion by stimulating the expression of CYP11A, 3beta-hydroxysteroid dehydrogenase, and steroidogenic acute regulatory protein in luteal cells Mus musculus