EC Number   |
Expression |
Reference |
|---|
   3.4.24.11 | down |
decreased expresssion upon treatment with Cu2+ |
717699 |
| 3.4.24.11 | down |
NEP expression is down-regulated in bovine vascular endothelial cells by physiological laminar shear, possibly via a mechanotransduction mechanism involving NADPH oxidase-induced reactive oxygen species production |
708750 |
| 3.4.24.11 | down |
treatment of neuroblastoma cells NB7 with 10 mM L685,458 a potent gamma-secretase inhibitor substantially reduces NEP expression |
708333 |
| 3.4.24.11 | up |
ethanol induces an increase in NEP mRNA in the frontal cortex |
718015 |
| 3.4.24.11 | up |
in neuroblastoma SH-SY5Y cells neprilysin expression is up-regulated estrogen. Upregulation of neprilysin by estrogen is dependent on both estrogen receptor alpha and beta, and ligand-activated estrogen receptor regulates expression of neprilysin through physical interactions between estrogen receptor and estrogen response elements identified in the neprilysin gene |
709162 |
| 3.4.24.11 | up |
six-week intermittent hypoxia increases NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex. The increase in NEP activity and expression is reverted followed by two weeks recovery in normoxia |
-, 754906 |
| 3.4.24.11 | up |
treatment of cells with and histone deacetylase inhibitor sodium valproate or trichostatin A significantly increases NEP mRNA levels and NEP enzymatic activity in neuroblastoma SH-SY5Y cells |
708333 |
