Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell line | two neuroblastoma cell lines differing substantially in NEP expression are compared: using chromatin immunoprecipitation it is shown that amyloid precursor protein is bound directly to the NEP promoter in high NEP-expresser (NB7) cells but not in low-expresser (SH-SY5Y) cells. The methylation status of the NEP promoter does not regulate expression in these cells, whereas the histone deacetylase inhibitors trichostatin A and valproate partly restore NEP expression and activity in SH-SY5Y cells | Homo sapiens | - |
neuron | chromatin immunoprecipitation analysis demonstrates amyloid precursor protein binding to tht NEP promoter in primary neurons | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
NEP | - |
Homo sapiens |
NEP | - |
Rattus norvegicus |
neprilysin | - |
Homo sapiens |
neprilysin | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | treatment of neuroblastoma cells NB7 with 10 mM L685,458 a potent gamma-secretase inhibitor substantially reduces NEP expression | down |
Homo sapiens | treatment of cells with and histone deacetylase inhibitor sodium valproate or trichostatin A significantly increases NEP mRNA levels and NEP enzymatic activity in neuroblastoma SH-SY5Y cells | up |