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EC Number Posttranslational Modification Commentary Reference
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45acetylation Nalpha-acetylation inhibits thymidylate degradation, Pro-2 protects the N terminus against Nalpha-acetylation 704570
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45phosphoprotein phosphorylation of serine 124 in human thymidylate synthase lowers the catalytic activity of the enzyme. The phosphorylation changes the collective motions of the enzyme, consisting of the suppression of motions especially in the regions flanking the entrance to the active site 719078
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45phosphoprotein phosphorylation of the wild type enzyme by casein kinase 2 is selective for the inactive conformation. dUMP inhibits phosphorylation of the wild type enzyme 720995
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