EC Number   |
Application |
Reference |
|---|
   3.4.21.109 | diagnostics |
the enzyme is a useful marker for mast cells |
683423 |
| 3.4.21.109 | diagnostics |
the enzyme might be a good biomarker in treatment of malignant breast tumors |
683514 |
| 3.4.21.109 | drug development |
matriptase-2 represents a target for the development of inhibitors, potentially useful in the treatment of hemochromatosis or beneficial as pharmacological tools |
731663 |
| 3.4.21.109 | drug development |
the enzyme is a potential target in anti-cancer therapy |
683343 |
| 3.4.21.109 | medicine |
coexpression of matriptase with amyloid precursor protein APP695 results in site-specific cleavagesof amyloid precursor protein. Replacement of Arg-601 (Arg-5 in Abeta1-42) by Ala in APP695 prevents matriptase cleavage at this site. Overexpression of matriptase in M17 cells results in a significant reduction of the endogenous amyloid precursor protein quantity |
753107 |
| 3.4.21.109 | medicine |
expression of serine protease SNC19/matripase and hepatocyte growth factor is decreased in gastrointestinal cancer tissues compared to their normal counterparts, decreased expression may correlate with invasion and lymph node metastasis |
677254 |
| 3.4.21.109 | medicine |
in breast cancer cells, a significant amount of the 30-40-kDa serine protease inhibitor HAI-2 can translocate to and inhibit matriptase on the cell surface, followed by shedding of the matriptase-HAI-2 complex |
755095 |
| 3.4.21.109 | medicine |
inhibition of matriptase appears to suppress both primar tumor growth and metastasis, leading to considerable interest in the development of potent matriptase inhibitors as anti-cancer drugs |
695506 |
| 3.4.21.109 | medicine |
loss of cell surface protease inhibitor HAI-2 in intestinal epithelial cells leads to unrestrained matriptase activity and efficient cleavage of epithelial cell adhesion molecule EPCAM. Congenital tufting enteropathy-associated HAI-2 mutant proteins exhibit reduced ability to inhibit matriptase and also fail to efficiently stabilize claudin-7 in intestinal epithelial cells |
754259 |
| 3.4.21.109 | medicine |
matripase mediates cell invasion through activation of receptor-bound pro-urokinase-type plasminogen activator |
674410 |
