Literature summary for 3.4.21.109 extracted from

Janciauskiene, S.; Nita, I.; Subramaniyam, D.; Li, Q.; Lancaster, J.R.; Matalon, S.
Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro (2008), Am. J. Respir. Cell Mol. Biol., 39, 631-637.

Search for more literature for 3.4.21.109

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	auto-activating protease	Homo sapiens

Application

Application	Comment	Organism
medicine	inhibition of matriptase appears to suppress both primar tumor growth and metastasis, leading to considerable interest in the development of potent matriptase inhibitors as anti-cancer drugs	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
amino acid residues 596 to 855 and 615 to 855, corresponding to the active sites and catalytic domains of the peptide, respectively, are expressed with a N-terminal His tag in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha1-antitrypsin	AAT	Homo sapiens
hepatocyte growth factor activator inhibitor	HAI-1	Homo sapiens
sunflower trypsin inhibitor	SFTI-1	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
26000	-	determined by SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
using a metal chelating column and a gel filtration column	Homo sapiens

Renatured (Commentary)

Renatured (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	-	Homo sapiens	-
additional information	matriptase is expressed in prostate, breast and colorectal cancers in vitro and in vivo	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O	enzymatic activity assay	Homo sapiens	t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
epithin	-	Homo sapiens
matriptase	-	Homo sapiens
MT-SP1	-	Homo sapiens
ST14	-	Homo sapiens
suppressor of tumorigenicity 14	-	Homo sapiens
TADG15	-	Homo sapiens
type II transmembrane protease	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9	-	enzymatic activity assay	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000092	-	sunflower trypsin inhibitor	-	Homo sapiens

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Release 2023.1 (January 2023)