EC Number   |
Application |
Reference |
|---|
   3.1.4.12 | diagnostics |
the extracellular enzyme from cerebrospinal fluid might hava a value as a potential biomarker for disease type, severity, progress or therapeutic success |
730731 |
| 3.1.4.12 | diagnostics |
the fecal sphingomyelinase activity reflects the human intestinal mucosa enzyme level and represents a new marker for human colorectal adenocarcinoma, mainly taking into account its early appearance in intestinal neoplasms |
664495 |
| 3.1.4.12 | drug development |
acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus,the enzym eis a target for drug development |
730294 |
| 3.1.4.12 | drug development |
TbnSMase is therefore genetically validated as a drug target against African trypanosomes, and suggests that interfering with the endocytic transport of variant surface glycoprotein is a highly desirable strategy for drug development against African trypanosomasis |
716252 |
| 3.1.4.12 | medicine |
acid sphingomyelinase activity and sphingomyelin presence are necessary for efficient infection of cells by ebolavirus, inhibition of the enzyme might be a threpeutic way |
730294 |
| 3.1.4.12 | medicine |
activation of acid sphingomyelinase is necessary and sufficient for microparticle release from glial cells and define key molecular effectors of microparticle formation and IL-1beta release, thus, opening new strategies for the treatment of neuroinflammatory diseases |
692073 |
| 3.1.4.12 | medicine |
ASM plays a complex and varied role in brain development, as well as in the pathogenesis of several common neurological diseases, ASM is particularly intriguing as an antioncogenic drug, ASM is associated with the type A Niemann-Pick disease, atherosclerosis, Wilson disease, hepatic autoimmune disease, alcohol-induced liver disease, cerebral ischemia, emphysema, cystic fibrosis, and cancer |
692274 |
| 3.1.4.12 | medicine |
inhibiting or stopping N-SMase activity is an important strategy to prevent neuron death from ischemia |
666445 |
| 3.1.4.12 | medicine |
intrarectal instillation of recombinant human Alk-SMase once daily for 1 week significantly reduces the inflammation score and protects the colonic epithelium from inflammatory destruction in a rat colitis model |
692009 |
| 3.1.4.12 | medicine |
Niemann-Pick A disease is a lysosomal storage disorder caused by a deficiency in acid sphingomyelinase activity, repeated intracerebroventricular infusions of recombinant human acid sphingomyelinase reduce the aberrant lysosomal accumulation of cholesterol and are effective at improving the disease phenotype in the acid sphingomyelinase-knockout mouse as indicated by a partial alleviation of the motor abnormalities |
692236 |
