EC Number   |
Application |
Reference |
|---|
   1.4.3.13 | diagnostics |
co-overexpression of SP1 and LOXL2 significantly correlates with poor prognosis in patients with pancreatic cancer |
765826 |
| 1.4.3.13 | diagnostics |
LOX can serve as a predictive marker of lymph node metastasis and prognosis in esophageal squamous cell carcinoma. Overall survival rates of the patients with esophageal squamous cell carcinoma with high LOX expression are significantly lower than those of the patients with esophageal squamous cell carcinoma with low LOX expression |
695612 |
| 1.4.3.13 | medicine |
an extracellular matrix (ECM)-targeting nanotherapeutic is engineered using a lipid-based nanoparticle chemically linked to an inhibitor of the ECM-related enzyme, lysyl oxidase 1 (LOX), that inhibits the crosslinking of elastin and collagen fibers. When the conjugated vesicles are loaded with the chemotherapeutic epirubicin, superior inhibition of triple negative breast cancer (TNBC) cell growth is observed both in vitro and in vivo |
765791 |
| 1.4.3.13 | medicine |
chronic inhalation of cadmium induces emphysema. Long-term Cd exposure induces inhibition of Cu-dependent lysyl oxidase and its substrates, by upregulation of Cu scavenging thiols in pulmonary fibroblasts. Downregulation of lysyl oxidase results from limitated Cu bioavailability as a central event contributing to Cd-induced extracellular matrix damage. Restoration of LO levels in Cd-insulted lung cells or tissues by replenishing Cu may have a protective or therapeutic effect on Cd-induced emphysema |
677209 |
| 1.4.3.13 | medicine |
cutis laxa, indicated by hyperextensible skin with marked deficiency of skin elastic fibers, is caused by deficiency of lysyl oxidase expression. Fibrosis is a symptom of scleroderma, where lysyl oxidase is markedly elevated in affected tissues. Menkes syndrome may involve abnormalities in the expression of several genes coding for connective tissue proteins |
391742 |
| 1.4.3.13 | medicine |
genetic variation in the LOXL1 gene might play a role as a risk factor for spontaneous cervical artery dissection |
686038 |
| 1.4.3.13 | medicine |
increase in the expression of lysyl oxidase during wound healing in skin and in aorta, lung and skin of developing and aging rats. Implication of lysyl oxidase as a target gene for IRF-1 in tumor suppression. Lysly oxidase has unusual and important roles in cellular homeostasis |
391742 |
| 1.4.3.13 | medicine |
LOX could play a key role in vascular homeostasis and, hence, it emerges as a new player in cardiovascular diseases |
685981 |
| 1.4.3.13 | medicine |
LOX inhibition might be useful in metastasis prevention, metastasis model and drug administration study in mice, overview |
700903 |
| 1.4.3.13 | medicine |
LOX is a potent metastasis-promoting gene in breast carcinomas that facilitates metastatic tumor progression by inducing cell motility and migration and has the potential for novel anti-metastatic cancer therapeutics |
687919 |
