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EC Number
Localization
Commentary
GeneOntology No.
Reference
3.4.24.86
cell surface
-
GO:0009986
AmiGO
QuickGO
638989
,
638994
,
638995
,
639003
,
639006
3.4.24.86
cell surface
most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface
GO:0009986
AmiGO
QuickGO
755446
3.4.24.86
cytoplasm
-
GO:0005737
AmiGO
QuickGO
-
,
638989
,
638991
,
639002
,
639006
3.4.24.86
cytoplasm
ADAM-17 is located diffusely within the cell cytoplasm, and treatment with TNF-alpha does not alter the level of expression or the cytoplasmic distribution of ADAM-17
GO:0005737
AmiGO
QuickGO
712819
3.4.24.86
cytoplasm
cytoplasmic tail
GO:0005737
AmiGO
QuickGO
-
,
638984
,
638985
,
638987
,
638994
3.4.24.86
cytoplasm
TACE is located in the cytoplasm of IFN gamma-treated cells
GO:0005737
AmiGO
QuickGO
682211
3.4.24.86
cytoskeleton
only the mature form of ADAM-17 associates with the cytoskeleton
GO:0005856
AmiGO
QuickGO
681031
3.4.24.86
cytosol
cytosolic tail of TACE precedes TACE activation
GO:0005829
AmiGO
QuickGO
638982
3.4.24.86
endoplasmic reticulum
-
GO:0005783
AmiGO
QuickGO
638994
3.4.24.86
endosome
-
GO:0005768
AmiGO
QuickGO
667464
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