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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.B11more identification of a specific protease-activating RNA motif PARM located in the pol region of viral RNA, which stimulates protease activity in vitro and in vivo. PARM spans the A and B regions of the central purine-rich sequences of the prototype foamy virus (pre)genomic RNA. PARM enables foamy virus protease-reverse transcriptase to form a proteolytically active dimer in vitro as well as in vivo. At least two foamy virus protease-reverse transcriptase molecules bind to the PARM and only RNAs containing the PARM result in significant activation of the protease. DNA harboring the PARM is not capable of protease activation.The PARM displays a distinct RNA folding, important for protease activation and thus virus maturation 718058
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.B11NaCl assay at 3 M, no activity at salt concentrations of 0.2-0.4 M Na. In vitro dimerization of the protease domain is inducible at high salt concentrations. This effect might be caused by a hydrophobic dimerization interface, which under high ionic strength disfavors the monomeric state 718389
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