EC Number   |
Activating Compound |
Reference |
|---|
    2.1.2.1 | 5,6,7,8-tetrahydrofolate |
control of SHMT activity by the availability of 5,6,7,8-tetrahydrofolate |
671499 |
| 2.1.2.1 | CO(NH2)2 |
activates |
736753 |
| 2.1.2.1 | EDTA |
101.25% activity at 1% (v/v) |
756288 |
| 2.1.2.1 | EDTA |
activates |
736753 |
| 2.1.2.1 | L-serine |
stabilizes the dimeric form of the enzyme |
718984 |
| 2.1.2.1 | more |
higher concentrations of IPTG, increased induction temperature and/or prolonged induction time increase the ratio of insoluble and soluble SHMT-1 |
676954 |
| 2.1.2.1 | more |
in the presence of 1mM dithiothreitol + 1mM pyridoxal 5-phosphate + 20 mM EDTA: 29fold increase in the specific activity |
441403 |
| 2.1.2.1 | more |
recombinant dominant negative SHMT1, DN2-SHMT1, localizes with lamin B1 and enhances SHMT1 activity for de novo thymidylate biosynthesis |
720054 |
| 2.1.2.1 | pyridoxal 5'-phosphate |
- |
671499, 671589 |
| 2.1.2.1 | pyridoxal phosphate |
- |
673412 |
