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Gene ontology
Version 2014-12-22
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Details for exo-alpha-sialidase activity
3.2.1.18
Gene ontology ID
GO:0004308
Definition
Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
Synonyms
1. acetylneuraminidase activity
2. acetylneuraminyl hydrolase activity
3. alpha-neuraminidase activity
4. N-acylneuraminate glycohydrolase activity
5. neuraminidase activity
6. sialidase activity
References
1. EC 3.2.1.18
2. MetaCyc 3.2.1.18-RXN
3. Reactome: R-HSA-1605723 "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol)"
4. Reactome: R-HSA-1605724 "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)"
5. Reactome: R-HSA-1605768 "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)"
6. Reactome: R-HSA-168870 "Neuraminidase enzymatic release from sialic acid"
7. Reactome: R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates"
8. Reactome: R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates"
9. Reactome: R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates"
10. Reactome: R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates"
11. Reactome: R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
hydrolase activity is a
hydrolase activity, acting on glycosyl bonds is a
hydrolase activity, hydrolyzing O-glycosyl compounds is a
alpha-sialidase activity is a
exo-alpha-sialidase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
hydrolase activity, hydrolyzing N-glycosyl compounds is a
hydrolase activity, hydrolyzing O-glycosyl compounds is a
2,6-beta-fructan 6-levanbiohydrolase activity is a
2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity is a
2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity is a
3-deoxy-2-octulosonidase activity is a
3-deoxyoctulosonase activity is a
4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity is a
6-O-methyl-deacetylisoipecoside beta-glucosidase activity is a
acyl-glucuronidase activity is a
alpha-agarase activity is a
alpha-amylase activity (releasing maltohexaose) is a
alpha-D-xyloside xylohydrolase is a
alpha-glucuronidase activity is a
alpha-L-arabinofuranosidase activity is a
alpha-L-rhamnosidase activity is a
alpha-neoagaro-oligosaccharide hydrolase activity is a
alpha-sialidase activity is a
3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity is a
endo-alpha-(2,8)-sialidase activity is a
exo-alpha-sialidase activity is a
exo-alpha-(2->3)-sialidase activity is a
exo-alpha-(2->6)-sialidase activity is a
exo-alpha-(2->8)-sialidase activity is a
amylase activity is a
amylopectin maltohydrolase activity is a
arabinan endo-1,5-alpha-L-arabinosidase activity is a
baicalin beta-D-glucuronidase activity is a
beta-6-sulfate-N-acetylglucosaminidase activity is a
beta-agarase activity is a
beta-D-fucosidase activity is a
beta-fructofuranosidase activity is a
beta-galactofuranosidase activity is a
beta-glucanase activity is a
beta-glucuronidase activity is a
beta-L-arabinofuranosidase activity is a
beta-L-arabinosidase activity is a
beta-L-rhamnosidase activity is a
beta-primeverosidase activity is a
cellulase activity is a
cellulose 1,4-beta-cellobiosidase activity is a
cellulose 1,4-beta-cellobiosidase activity (reducing end) is a
chitinase activity is a
chitosanase activity is a
cyanidin 3,5-diglucoside glucosidase activity is a
cyanidin 3,7-diglucoside glucosidase activity is a
cyclomaltodextrinase activity is a
d-4,5 unsaturated beta-glucuronyl hydrolase activity is a
dalcochinase activity is a
dextran 1,6-alpha-isomaltotriosidase activity is a
dextranase activity is a
difructose-anhydride synthase activity is a
DIMBOA glucoside beta-D-glucosidase activity is a
endo-1,3-alpha-L-rhamnosidase activity is a
endo-xylogalacturonan hydrolase activity is a
endoglycosylceramidase activity is a
exo-1,4-beta-D-glucosaminidase activity is a
exo-poly-alpha-galacturonosidase activity is a
fructan beta-(2,1)-fructosidase activity is a
fructan beta-(2,6)-fructosidase activity is a
fructan beta-fructosidase activity is a
fucoidanase activity is a
fucosidase activity is a
galactosidase activity is a
galactosylceramidase activity is a
galactosylgalactosylglucosylceramidase activity is a
galacturan 1,4-alpha-galacturonidase activity is a
GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity is a
glucan 1,4-alpha-maltohexaosidase activity is a
glucan 1,4-alpha-maltohydrolase activity is a
glucan 1,4-alpha-maltotetraohydrolase activity is a
glucan 1,4-alpha-maltotriohydrolase activity is a
glucan 1,6-alpha-isomaltosidase activity is a
glucosidase activity is a
glucosinolate glucohydrolase activity is a
glucosylceramidase activity is a
glucuronosyl-disulfoglucosamine glucuronidase activity is a
glycosylceramidase activity is a
glycuronidase activity is a
glycyrrhizinate beta-glucuronidase activity is a
heparanase activity is a
hexosaminidase activity is a
hyaluronoglucuronidase activity is a
inulinase activity is a
iota-carrageenase activity is a
isoamylase (maltodextrin-releasing) activity is a
isoflavone-7-O-glucoside beta-glucosidase activity is a
isopullulanase activity is a
kappa-carrageenase activity is a
L-iduronidase activity is a
lactase activity is a
lacto-N-biosidase activity is a
lambda-carrageenase activity is a
levanase activity is a
licheninase activity is a
limit dextrinase activity is a
linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity is a
lysozyme activity is a
mannan 1,4-mannobiosidase activity is a
mannosidase activity is a
mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity is a
methyl beta-D-glucoside 6-phosphate glucohydrolase activity is a
mucinaminylserine mucinaminidase activity is a
mycodextranase activity is a
N,N'-diacetylchitobiose synthase activity is a
N-acetyl-beta-D-galactosaminidase activity is a
neo-lambda-carrahexaose hydrolase activity is a
neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity is a
neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity is a
neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity is a
neopullulanase activity is a
oligosaccharide reducing-end xylanase activity is a
oligoxyloglucan reducing-end-specific cellobiohydrolase activity is a
peptidoglycan beta-N-acetylmuramidase activity is a
poly(ADP-ribose) glycohydrolase activity is a
polygalacturonase activity is a
polymannuronate hydrolase activity is a
pullulanase activity is a
quercitrinase activity is a
scopolin beta-glucosidase activity is a
thioglucosidase activity is a
trehalase activity is a
UDP-N,N'-diacetylbacillosamine 2-epimerase activity is a
unsaturated chondroitin disaccharide hydrolase activity is a
unsaturated rhamnogalacturonyl hydrolase activity is a
xylan alpha-1,2-glucuronosidase activity is a
xylanase activity is a
xyloglucan 1,6-alpha-xylosidase activity is a
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity is a
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity is a
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity is a
sulfoquinovosidase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a