Reference on EC 6.5.1.2 - DNA ligase (NAD+) and Organism(s) Escherichia coli and UniProt Accession P15042
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Engler, M.J.; Richardson, C.C.
DNA ligases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
15
3-29
1982
Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
-
Maunders, M.J.
DNA and RNA ligases (EC 6.5.1.1, EC 6.5.1.2, and EC 6.5.1.3)
Methods Mol. Biol.
16
213-230
1993
Bacillus subtilis, Escherichia coli, Thermus thermophilus, Salmonella enterica subsp. enterica serovar Typhimurium
Hayashi, K.; Nakazawa, M.; Ishizaki, Y.; Hiraoka, N.; Obayashi, A.
Stimulation of intermolecular ligation with E. coli DNA ligase by high concentrations of monovalent cations in polyethylene glycol solutions
Nucleic Acids Res.
13
7979-7992
1985
Escherichia coli
Zimmerman, S.B.; Pheiffer, B.H.
Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli
Proc. Natl. Acad. Sci. USA
80
5852-5856
1983
Escherichia coli
Higgins, N.P.; Cozzarelli, N.R.
DNA-joining enzymes: A review
Methods Enzymol.
68
50-71
1979
Escherichia coli
Panasenko, S.M.; Alazard, R.J.; Lehman, I.R.
A simple, three-step procedure for the large scale purification of DNA ligase from a hybrid lysogen constructed in vitro
J. Biol. Chem.
253
4590-4592
1978
Escherichia coli
Modrich, P.; Anraku, Y.; Lehman, I.R.
Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogenous enzyme from Escherichia coli
J. Biol. Chem.
248
7475-7501
1973
Escherichia coli
-
Georlette, D.; Jonsson, Z.O.; Van Petegem, F.; Chessa, J.P.; Van Beeumen, J.; Hubscher, U.; Gerday, C.
A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures
Eur. J. Biochem.
267
3502-3512
2000
Escherichia coli, Thermus scotoductus, Pseudoalteromonas haloplanktis (Q9RBF2)
Lim, J.H.; Choi, J.; Han, S.J.; Kim, S.H.; Hwang, H.Z.; Jin, D.K.; Ahn, B.Y.; Han, Y.S.
Molecular cloning and characterization of thermostable DNA ligase from Aquifex pyrophilus, a hyperthermophilic bacterium
Extremophiles
5
161-168
2001
Aquifex pyrophilus (Q9F150), Escherichia coli, Thermus aquaticus
Sriskanda, V.; Shuman, S.
Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+
J. Biol. Chem.
277
9695-9700
2002
Escherichia coli
Brotz-Oesterhelt, H.; Knezevic, I.; Bartel, S.; Lampe, T.; Warnecke-Eberz, U.; Ziegelbauer, K.; Habich, D.; Labischinski, H.
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones
J. Biol. Chem.
278
39435-39442
2003
Escherichia coli
Georlette, D.; Blaise, V.; Dohmen, C.; Bouillenne, F.; Damien, B.; Depiereux, E.; Gerday, C.; Uversky, V.N.; Feller, G.
Cofactor Binding modulates the conformational stabilities and unfolding patterns of NAD+-dependent DNA ligases from Escherichia coli and Thermus scotoductus
J. Biol. Chem.
278
49945-49953
2003
Escherichia coli, Thermus scotoductus
Sriskanda, V.; Schwer, B.; Ho, C.K.; Shuman, S.
Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4
Nucleic Acids Res.
27
3953-3963
1999
Escherichia coli
Sriskanda, V.; Shuman, S.
A second NAD+-dependent DNA ligase (LigB) in Escherichia coli
Nucleic Acids Res.
29
4930-4934
2001
Escherichia coli
Wilkinson, A.; Sayer, H.; Bullard, D.; Smith, A.; Day, J.; Kieser, T.; Bowater, R.
NAD+-dependent DNA ligases of Mycobacterium tuberculosis and Streptomyces coelicolor
Proteins Struct. Funct. Genet.
51
321-326
2003
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Zauner, G.; Wang, Y.; Lavesa-Curto, M.; MacDonald, A.; Mayes, A.G.; Bowater, R.P.; Butt, J.N.
Tethered DNA hairpins facilitate electrochemical detection of DNA ligation
Analyst
130
345-349
2005
Escherichia coli
Wilkinson, A.; Smith, A.; Bullard, D.; Lavesa-Curto, M.; Sayer, H.; Bonner, A.; Hemmings, A.; Bowater, R.
Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA)
Biochim. Biophys. Acta
1749
113-122
2005
Escherichia coli
Zhu, H.; Shuman, S.
Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA)
J. Biol. Chem.
280
12137-12144
2005
Escherichia coli
Lavesa-Curto, M.; Sayer, H.; Bullard, D.; MacDonald, A.; Wilkinson, A.; Smith, A.; Bowater, L.; Hemmings, A.; Bowater, R.P.
Characterization of a temperature-sensitive DNA ligase from Escherichia coli
Microbiology
150
4171-4180
2004
Escherichia coli, Escherichia coli DSM 3757
Miesel, L.; Kravec, C.; Xin, A.T.; McMonagle, P.; Ma, S.; Pichardo, J.; Feld, B.; Barrabee, E.; Palermo, R.
A high-throughput assay for the adenylation reaction of bacterial DNA ligase
Anal. Biochem.
366
9-17
2007
Escherichia coli
Nandakumar, J.; Nair, P.A.; Shuman, S.
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate
Mol. Cell
26
257-271
2007
Escherichia coli (P15042)
Vacek, J.; Cahova, K.; Palecek, E.; Bullard, D.R.; Lavesa-Curto, M.; Bowater, R.P.; Fojta, M.
Label-free electrochemical monitoring of DNA ligase activity
Anal. Chem.
80
7609-7613
2008
Escherichia coli
Li, J.; Jiang, J.H.; Xu, X.M.; Chu, X.; Jiang, C.; Shen, G.; Yu, R.Q.
Simultaneous identification of point mutations via DNA ligase-mediated gold nanoparticle assembly
Analyst
133
939-945
2008
Escherichia coli
Pascal, J.M.
DNA and RNA ligases: structural variations and shared mechanisms
Curr. Opin. Struct. Biol.
18
96-105
2008
Escherichia coli, Enterococcus faecalis, Thermus filiformis
Wang, L.K.; Nair, P.A.; Shuman, S.
Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase
J. Biol. Chem.
283
23343-23352
2008
Escherichia coli (P15042)
Dwivedi, N.; Dube, D.; Pandey, J.; Singh, B.; Kukshal, V.; Ramachandran, R.; Tripathi, R.P.
NAD+-dependent DNA ligase: a novel target waiting for the right inhibitor
Med. Res. Rev.
28
545-568
2008
Escherichia coli, Geobacillus stearothermophilus (O87703), Mycobacterium tuberculosis (P9WNV1), Enterococcus faecalis (Q837V6), Thermus filiformis (Q9ZHI0), Mycobacterium tuberculosis H37Rv (P9WNV1)
Luan, Q.; Xue, Y.; Yao, X.; Lu, W.
Hairpin DNA probe based surface plasmon resonance biosensor used for the activity assay of E. coli DNA ligase
Analyst
135
414-418
2010
Escherichia coli
Shuman, S.
DNA ligases: progress and prospects
J. Biol. Chem.
284
17365-17369
2009
Escherichia coli (P15042), Enterococcus faecalis (Q837V6)
Mills, S.D.; Eakin, A.E.; Buurman, E.T.; Newman, J.V.; Gao, N.; Huynh, H.; Johnson, K.D.; Lahiri, S.; Shapiro, A.B.; Walkup, G.K.; Yang, W.; Stokes, S.S.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo
Antimicrob. Agents Chemother.
55
1088-1096
2011
Escherichia coli, Escherichia coli MG1655, Haemophilus influenzae, Haemophilus influenzae KW20, Mycoplasma pneumoniae, Mycoplasma pneumoniae M29, Staphylococcus aureus, Staphylococcus aureus RN4220, Streptococcus pneumoniae
Akhoon, B.A.; Gupta, S.K.; Dhaliwal, G.; Srivastava, M.; Gupta, S.K.
Virtual screening of specific chemical compounds by exploring E.coli NAD+-dependent DNA ligase as a target for antibacterial drug discovery
J. Mol. Model.
17
265-273
2011
Escherichia coli
He, X.; Ni, X.; Wang, Y.; Wang, K.; Jian, L.
Electrochemical detection of nicotinamide adenine dinucleotide based on molecular beacon-like DNA and E. coli DNA ligase
Talanta
83
937-942
2011
Escherichia coli
Wang, T.; Duncan, L.; Gu, W.; ODowd, H.; Wei, Y.; Perola, E.; Parsons, J.; Gross, C.H.; Moody, C.S.; Arends, S.J.; Charifson, P.S.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
Bioorg. Med. Chem. Lett.
22
3699-3703
2012
Escherichia coli
Surivet, J.P.; Lange, R.; Hubschwerlen, C.; Keck, W.; Specklin, J.L.; Ritz, D.; Bur, D.; Locher, H.; Seiler, P.; Strasser, D.S.; Prade, L.; Kohl, C.; Schmitt, C.; Chapoux, G.; Ilhan, E.; Ekambaram, N.; Athanasiou, A.; Knezevic, A.; Sabato, D.; Chambovey, A.; Gaertner, M.; Enderlin, M.; Boehme, M.; Sipp, S.i.p.p.e.
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
Bioorg. Med. Chem. Lett.
22
6705-6711
2012
Escherichia coli
Jiang, C.; Kan, Y.Y.; Jiang, J.H.; Yu, R.Q.
A simple and highly sensitive DNAzyme-based assay for nicotinamide adenine dinucleotide by ligase-mediated inhibition of strand displacement amplification
Anal. Chim. Acta
844
70-74
2014
Escherichia coli
Murphy-Benenato, K.E.; Gingipalli, L.; Boriack-Sjodin, P.A.; Martinez-Botella, G.; Carcanague, D.; Eyermann, C.J.; Gowravaram, M.; Harang, J.; Hale, M.R.; Ioannidis, G.; Jahic, H.; Johnstone, M.; Kutschke, A.; Laganas, V.A.; Loch, J.T.; Miller, M.D.; Oguto, H.; Patel, S.J.
Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development
Bioorg. Med. Chem. Lett.
25
5172-5177
2015
Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Haemophilus influenzae ARM158, Escherichia coli ARC524, Streptococcus pneumoniae ARC548, Staphylococcus aureus ARC561
Pergolizzi, G.; Wagner, G.K.; Bowater, R.P.
Biochemical and structural characterisation of DNA ligases from bacteria and archaea
Biosci. Rep.
36
e00391
2016
Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Mycobacterium tuberculosis, Mycoplasma pneumoniae
Chauleau, M.; Shuman, S.
Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD+-dependent DNA ligase (LigA)
Nucleic Acids Res.
44
2298-2309
2016
Escherichia coli
Konomura, N.; Arai, N.; Shinohara, T.; Kobayashi, J.; Iwasaki, W.; Ikawa, S.; Kusano, K.; Shibata, T.
Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions
Nucleic Acids Res.
45
337-352
2017
Escherichia coli
Pergolizzi, G.; Cominetti, M.M.; Butt, J.N.; Field, R.A.; Bowater, R.P.; Wagner, G.K.
Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases
Org. Biomol. Chem.
13
6380-6398
2015
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv