Reference on EC 6.1.1.4 - leucine-tRNA ligase and Organism(s) Homo sapiens and UniProt Accession Q9P2J5
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bullard, J.M.; Cai, Y.C.; Spremulli, L.L.
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
Biochim. Biophys. Acta
1490
245-258
2000
Homo sapiens (Q15031), Homo sapiens
Yao, Y.N.; Wang, L.; Wu, X.F.; Wang, E.D.
Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli
Protein Expr. Purif.
30
112-116
2003
Homo sapiens
Lue, S.W.; Kelley, S.O.
An aminoacyl-tRNA synthetase with a defunct editing site
Biochemistry
44
3010-3016
2005
Escherichia coli, Homo sapiens
Ling, C.; Yao, Y.N.; Zheng, Y.G.; Wei, H.; Wang, L.; Wu, X.F.; Wang, E.D.
The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex
J. Biol. Chem.
280
34755-34763
2005
Homo sapiens
Sohm, B.; Sissler, M.; Park, H.; King, M.P.; Florentz, C.
Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase
J. Mol. Biol.
339
17-29
2004
Homo sapiens
Lue, S.W.; Kelley, S.O.
A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation
Biochemistry
46
4466-4472
2007
Escherichia coli, Homo sapiens
Shin, S.H.; Kim, H.S.; Jung, S.H.; Xu, H.D.; Jeong, Y.B.; Chung, Y.J.
Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis
Exp. Mol. Med.
40
229-236
2008
Homo sapiens
Yao, P.; Zhou, X.L.; He, R.; Xue, M.Q.; Zheng, Y.G.; Wang, Y.F.; Wang, E.D.
Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain
J. Biol. Chem.
283
22591-22600
2008
Homo sapiens, Saccharomyces cerevisiae (P26637), Saccharomyces cerevisiae
Park, H.; Davidson, E.; King, M.P.
Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene
RNA
14
2407-2416
2008
Homo sapiens
Pang, Y.L.; Martinis, S.A.
A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase
Biochemistry
48
8958-8964
2009
Homo sapiens (Q9P2J5), Homo sapiens
Seiradake, E.; Mao, W.; Hernandez, V.; Baker, S.J.; Plattner, J.J.; Alley, M.R.; Cusack, S.
Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles
J. Mol. Biol.
390
196-207
2009
Candida albicans, Homo sapiens
Li, R.; Guan, M.X.
Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
Mol. Cell. Biol.
30
2147-2154
2010
Homo sapiens
Montanari, A.; De Luca, C.; Frontali, L.; Francisci, S.
Aminoacyl-tRNA synthetases are multivalent suppressors of defects due to human equivalent mutations in yeast mt tRNA genes
Biochim. Biophys. Acta
1803
1050-1057
2010
Homo sapiens
Chen, X.; Ma, J.J.; Tan, M.; Yao, P.; Hu, Q.H.; Eriani, G.; Wang, E.D.
Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
Nucleic Acids Res.
39
235-247
2011
Homo sapiens
Duran, R.V.; Hall, M.N.
Leucyl-tRNA synthetase: double duty in amino acid sensing
Cell Res.
22
1207-1209
2012
Saccharomyces cerevisiae, Homo sapiens
Han, J.M.; Jeong, S.J.; Park, M.C.; Kim, G.; Kwon, N.H.; Kim, H.K.; Ha, S.H.; Ryu, S.H.; Kim, S.
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
Cell
149
410-424
2012
Homo sapiens
Perli, E.; Giordano, C.; Pisano, A.; Montanari, A.; Campese, A.F.; Reyes, A.; Ghezzi, D.; Nasca, A.; Tuppen, H.A.; Orlandi, M.; Di Micco, P.; Poser, E.; Taylor, R.W.; Colotti, G.; Francisci, S.; Morea, V.; Frontali, L.; Zeviani, M.; dAmati, G.
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells
EMBO Mol. Med.
6
169-182
2014
Homo sapiens
Choi, H.; Son, J.B.; Kang, J.; Kwon, J.; Kim, J.H.; Jung, M.; Kim, S.K.; Kim, S.; Mun, J.Y.
Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane
Biochem. Biophys. Res. Commun.
493
1129-1135
2017
Homo sapiens
Yoon, M.S.; Son, K.; Arauz, E.; Han, J.M.; Kim, S.; Chen, J.
Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling
Cell Rep.
16
1510-1517
2016
Homo sapiens (Q9P2J5)
Kim, C.; Jung, J.; Tung, T.T.; Park, S.B.
beta-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase
Chem. Sci.
7
2753-2761
2016
Homo sapiens (Q9P2J5)
Perli, E.; Giordano, C.; Pisano, A.; Montanari, A.; Campese, A.F.; Reyes, A.; Ghezzi, D.; Nasca, A.; Tuppen, H.A.; Orlandi, M.; Di Micco, P.; Poser, E.; Taylor, R.W.; Colotti, G.; Francisci, S.; Morea, V.; Frontali, L.; Zeviani, M.; dAmati, G.
The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells
EMBO Mol. Med.
6
169-182
2014
Homo sapiens (Q15031), Homo sapiens
Giordano, C.; Morea, V.; Perli, E.; dAmati, G.
The phenotypic expression of mitochondrial tRNA-mutations can be modulated by either mitochondrial leucyl-tRNA synthetase or the C-terminal domain thereof
Front. Genet.
6
113
2015
Homo sapiens (Q15031), Homo sapiens
Yan, W.; Ye, Q.; Tan, M.; Chen, X.; Eriani, G.; Wang, E.D.
Modulation of aminoacylation and editing properties of leucyl-tRNA synthetase by a conserved structural module
J. Biol. Chem.
290
12256-12267
2015
Pyrococcus horikoshii (O58698), Aquifex aeolicus (O66680 AND O67646), Escherichia coli (P07813), Escherichia coli, Mesomycoplasma mobile (Q6KHA5), Homo sapiens (Q9P2J5), Mesomycoplasma mobile ATCC 43663 / 163K / NCTC 11711 (Q6KHA5), Pyrococcus horikoshii ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3 (O58698)
Gudzera, O.I.; Golub, A.G.; Bdzhola, V.G.; Volynets, G.P.; Kovalenko, O.P.; Boyarshin, K.S.; Yaremchuk, A.D.; Protopopov, M.V.; Yarmoluk, S.M.; Tukalo, M.A.
Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one
J. Enzyme Inhib. Med. Chem.
31
201-207
2016
Mycobacterium tuberculosis (P9WFV1), Mycobacterium tuberculosis, Homo sapiens (Q9P2J5), Homo sapiens, Mycobacterium tuberculosis ATCC 25618 / H37Rv (P9WFV1)
