Reference on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase and Organism(s) Escherichia coli and UniProt Accession P0A6L2
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shedlarski, J.G.
Pyruvate-aspartic semialdehyde condensing enzyme (Escherichia coli)
Methods Enzymol.
17B
129-134
1971
Escherichia coli
-
Shedlarski, J.G.; Gilvarg, C.
The pyruvate-aspartic semialdehyde condensing enzyme of Escherichia coli
J. Biol. Chem.
245
1362-1373
1970
Escherichia coli
Laber, B.; Gomis-Rueth, F.X.; Romao, M.J.; Huber, R.
Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization
Biochem. J.
268
691-695
1992
Escherichia coli
-
Mirwaldt, C.; Korndoerfer, I.; Huber, R.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli at 2.5 A resolution
J. Mol. Biol.
246
227-239
1995
Escherichia coli
Perl, A.; Shaul, O.; Galili, G.
Regulation of lysine synthesis in transgenic potato plants expressing a bacterial dihydrodipicolinate synthase in their chloroplasts
Plant Mol. Biol.
19
815-823
1992
Escherichia coli, Solanum tuberosum
Shaul, O.; Galili, G.
Concerted regulation of lysine and threonine synthesis in tobacco plants expressing bacterial feedback-insensitive aspartate kinase and dihydrodipicolinate synthase
Plant Mol. Biol.
23
759-768
1993
Escherichia coli, Nicotiana tabacum
Couper, L.; McKendrick, J.E.; Robins, D.J.
Pyridine and piperidine derivatives as inhibitors of dihydrdipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to L-lysine
Bioorg. Med. Chem. Lett.
4
2267-2272
1994
Escherichia coli
-
Karsten, W.E.
Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine
Biochemistry
36
1730-1739
1997
Escherichia coli
Blickling, S.; Knaeblein, J.
Feedback inhibition of dihydrodipicolinate synthase enzymes by L-lysine
Biol. Chem.
378
207-210
1997
Escherichia coli
Dobson, R.C.; Gerrard, J.A.; Pearce, F.G.
Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde
Biochem. J.
377
757-762
2004
Escherichia coli, Escherichia coli XL1-Blue
Dobson, R.C.; Valegard, K.; Gerrard, J.A.
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad
J. Mol. Biol.
338
329-339
2004
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Griffin, M.D.; Jameson, G.B.; Gerrard, J.A.
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance
Acta Crystallogr. Sect. D
61
1116-1124
2005
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Devenish, S.R.; Turner, L.A.; Clifford, V.R.; Pearce, F.G.; Jameson, G.B.; Gerrard, J.A.
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase
Biochemistry
44
13007-13013
2005
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Griffin, M.D.; Roberts, S.J.; Gerrard, J.A.
Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate
Biochimie
86
311-315
2004
Escherichia coli
Turner, J.J.; Gerrard, J.A.; Hutton, C.A.
Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive
Bioorg. Med. Chem.
13
2133-2140
2005
Escherichia coli
Mitsakos, V.; Dobson, R.C.; Pearce, F.G.; Devenish, S.R.; Evans, G.L.; Burgess, B.R.; Perugini, M.A.; Gerrard, J.A.; Hutton, C.A.
Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
Bioorg. Med. Chem. Lett.
18
842-844
2007
Escherichia coli, Mycobacterium tuberculosis, Staphylococcus aureus
Devenish, S.R.; Gerrard, J.A.; Jameson, G.B.; Dobson, R.C.
The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate
Acta Crystallogr. Sect. F
64
1092-1095
2008
Escherichia coli (P0A6L2), Escherichia coli
Pearce, F.G.; Dobson, R.C.; Weber, A.; Lane, L.A.; McCammon, M.G.; Squire, M.A.; Perugini, M.A.; Jameson, G.B.; Robinson, C.V.; Gerrard, J.A.
Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme
Biochemistry
47
12108-12117
2008
Escherichia coli (P0A6L2)
Boughton, B.A.; Griffin, M.D.; ODonnell, P.A.; Dobson, R.C.; Perugini, M.A.; Gerrard, J.A.; Hutton, C.A.
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues
Bioorg. Med. Chem.
16
9975-9983
2008
Escherichia coli (P0A6L2)
Boughton, B.A.; Dobson, R.C.; Gerrard, J.A.; Hutton, C.A.
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
Bioorg. Med. Chem. Lett.
18
460-463
2008
Escherichia coli (P0A6L2)
Dobson, R.C.; Griffin, M.D.; Devenish, S.R.; Pearce, F.G.; Hutton, C.A.; Gerrard, J.A.; Jameson, G.B.; Perugini, M.A.
Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase
Protein Sci.
17
2080-2090
2008
Escherichia coli (P0A6L2), Escherichia coli
Griffin, M.D.; Dobson, R.C.; Gerrard, J.A.; Perugini, M.A.
Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?
Arch. Biochem. Biophys.
494
58-63
2010
Escherichia coli (P0A6L2)
Guo, B.B.; Devenish, S.R.; Dobson, R.C.; Muscroft-Taylor, A.C.; Gerrard, J.A.
The C-terminal domain of Escherichia coli dihydrodipicolinate synthase (DHDPS) is essential for maintenance of quaternary structure and efficient catalysis
Biochem. Biophys. Res. Commun.
380
802-806
2009
Escherichia coli (P0A6L2), Escherichia coli
Devenish, S.R.; Huisman, F.H.; Parker, E.J.; Hadfield, A.T.; Gerrard, J.A.
Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis
Biochim. Biophys. Acta
1794
1168-1174
2009
Escherichia coli, Neisseria meningitidis (Q9JZR4), Neisseria meningitidis, Neisseria meningitidis MC58 (Q9JZR4)
Domigan, L.J.; Scally, S.W.; Fogg, M.J.; Hutton, C.A.; Perugini, M.A.; Dobson, R.C.; Muscroft-Taylor, A.C.; Gerrard, J.A.; Devenish, S.R.
Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis
Biochim. Biophys. Acta
1794
1510-1516
2009
Escherichia coli, Bacillus anthracis (Q81WN7), Bacillus anthracis
Dobson, R.C.; Perugini, M.A.; Jameson, G.B.; Gerrard, J.A.
Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis
Biochimie
91
1036-1044
2009
Escherichia coli (P0A6L2), Escherichia coli
Muscroft-Taylor, A.C.; Soares da Costa, T.P.; Gerrard, J.A.
New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry
Biochimie
92
254-262
2010
Thermotoga maritima, Escherichia coli (P0A6L2), Escherichia coli
Soares da Costa, T.P.; Muscroft-Taylor, A.C.; Dobson, R.C.; Devenish, S.R.; Jameson, G.B.; Gerrard, J.A.
How essential is the essential active-site lysine in dihydrodipicolinate synthase?
Biochimie
92
837-845
2010
Escherichia coli (P0A6L2), Escherichia coli
Devenish, S.R.; Blunt, J.W.; Gerrard, J.A.
NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase
J. Med. Chem.
53
4808-4812
2010
Escherichia coli
Muscroft-Taylor, A.C.; Catchpole, R.J.; Dobson, R.C.; Pearce, F.G.; Perugini, M.A.; Gerrard, J.A.
Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine
Arch. Biochem. Biophys.
503
202-206
2010
Escherichia coli
Blickling, S.; Renner, C.; Laber, B.; Pohlenz, H.; Holak, T.; Huber, R.
Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy
Biochemistry
36
24-33
1997
Escherichia coli (P0A6L2), Escherichia coli
Geng, F.; Chen, Z.; Zheng, P.; Sun, J.; Zeng, A.
Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production
Appl. Microbiol. Biotechnol.
97
1963-1971
2012
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032, Escherichia coli, Escherichia coli MG1655
Boughton, B.A.; Hor, L.; Gerrard, J.A.; Hutton, C.A.
1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase
Bioorg. Med. Chem.
20
2419-2426
2012
Escherichia coli
Reboul, C.F.; Porebski, B.T.; Griffin, M.D.; Dobson, R.C.; Perugini, M.A.; Gerrard, J.A.; Buckle, A.M.
Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase
PLoS Comput. Biol.
8
e1002537
2012
Escherichia coli, Staphylococcus aureus
Boughton, B.; Dobson, R.; Hutton, C.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product
Proteins
80
2117-2122
2012
Escherichia coli (P0A6L2), Escherichia coli
Karsten, W.E.; Nimmo, S.A.; Liu, J.; Chooback, L.
Identification of 2, 3-dihydrodipicolinate as the product of the dihydrodipicolinate synthase reaction from Escherichia coli
Arch. Biochem. Biophys.
653
50-62
2018
Escherichia coli, Escherichia coli JM109
Xu, J.; Han, M.; Ren, X.; Zhang, W.
Modification of aspartokinase III and dihydrodipicolinate synthetase increases the production of L-lysine in Escherichia coli
Biochem. Eng. J.
114
79-86
2016
Escherichia coli (P0A6L2), Escherichia coli LATR11 (P0A6L2)
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