Information on EC 4.2.1.137 - sporulenol synthase

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The expected taxonomic range for this enzyme is: Bacillus megaterium

EC NUMBER
COMMENTARY
4.2.1.137
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RECOMMENDED NAME
GeneOntology No.
sporulenol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
sporulenol = tetraprenyl-beta-curcumene + H2O
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
tetraprenyl-beta-curcumene-sporulenol cyclase
The reaction occurs in the reverse direction. Isolated from Bacillus subtilis. Similar sesquarterpenoids are present in a number of Bacillus species.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
sqhC
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gene name
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tetraprenyl-beta-curcumene cyclase
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bifunctional enzyme, cyclizing both tetraprenyl-beta-curcumene and squalene in vivo
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
metabolism
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tetraprenyl-beta-curcumene cyclase is bifunctional, cyclizing both tetraprenyl-beta-curcumene and squalene in vivo
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
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it is demonstrated that a tetraprenyl-beta-curcumene cyclase also cyclizes a tail-to-tail type of linear squalene into a bicyclic triterpenol, 8alpha-hydroxypolypoda-13,17,21-triene
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Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expressed in Escherichia coli
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