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Literature summary for 4.2.1.137 extracted from

  • Okamoto, W.; Sato, T.
    Enzymatic syntheses of unnatural head-to-tail pentacyclic triterpenes by tetraprenyl-beta-curcumene cyclase (2013), Tetrahedron Lett., 54, 6747-6750.
No PubMed abstract available
Search for more literature for 4.2.1.137

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus subtilis the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo ?
-
 ?
additional information Priestia megaterium the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo ?
-
 ?
tetraprenyl-beta-curcumene + H2O Bacillus subtilis
-
 baciterpenol A
-
 ?
tetraprenyl-beta-curcumene + H2O Priestia megaterium
-
 baciterpenol A
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Priestia megaterium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-hexaprene substrate specificity, overview. Enzymatic cyclization of head-to-tail acyclic triterpene beta-hexaprene, a natural product isolated from Bacillus clausii, by tetraprenyl-beta-curcumene cyclase from Bacillus subtilis results in the formation of two unnatural pentacyclic triterpenes. The enzyme can be used to construct the 6/6/6/6/6-fused pentacyclic scaffold in vitro, suggesting that the active site cavity of the enzyme has sufficient space to accommodate this unnatural pentacyclic scaffold Bacillus subtilis ?
-
 ?
beta-hexaprene substrate specificity, overview. Enzymatic cyclization of head-to-tail acyclic triterpene beta-hexaprene, a natural product isolated from Bacillus clausii, by tetraprenyl-beta-curcumene cyclase from Bacillus subtilis results in the formation of two unnatural pentacyclic triterpenes. The enzyme can be used to construct the 6/6/6/6/6-fused pentacyclic scaffold in vitro, suggesting that the active site cavity of the enzyme has sufficient space to accommodate this unnatural pentacyclic scaffold Priestia megaterium ?
-
 ?
additional information the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo Bacillus subtilis ?
-
 ?
additional information the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo Priestia megaterium ?
-
 ?
tetraprenyl-beta-curcumene + H2O
-
 Bacillus subtilis baciterpenol A
-
 ?
tetraprenyl-beta-curcumene + H2O
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 Priestia megaterium baciterpenol A
-
 ?

Synonyms

Synonyms Comment Organism
tetraprenyl-beta-curcumene cyclase
-
 Bacillus subtilis
tetraprenyl-beta-curcumene cyclase
-
 Priestia megaterium

General Information

General Information Comment Organism
evolution the enzyme is a sesquarterpene cyclase Bacillus subtilis
evolution the enzyme is a sesquarterpene cyclase Priestia megaterium
metabolism the enzyme is involved in biosynthetic pathway of sesquarterpenes (C35) and triterpenes (C30), overview Priestia megaterium
metabolism the enzyme is involved in biosynthetic pathway of sesquarterpenes (C35), overview Bacillus subtilis