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Literature summary for 4.2.1.137 extracted from

  • Sato, T.; Yoshida, S.; Hoshino, H.; Tanno, M.; Nakajima, M.; Hoshino, T.
    Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-beta-curcumene synthase and a tetraprenyl-beta-curcumene cyclase: identification of a new terpene cyclase (2011), J. Am. Chem. Soc., 133, 9734-9737.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene sqhC, expression in Escherichia coli using pColdTF Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tetraprenyl-alpha-curcumene + H2O Bacillus subtilis
-
 (1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol
-
 ?
tetraprenyl-alpha-curcumene + H2O Bacillus subtilis 168
-
 (1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis Q796C3 gene sqhC
-
Bacillus subtilis 168 Q796C3 gene sqhC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tetraprenyl-alpha-curcumene + H2O
-
 Bacillus subtilis (1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol
-
 ?
tetraprenyl-alpha-curcumene + H2O
-
 Bacillus subtilis (1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol the product is further converted by nonenzymatic autoxidation and thermal dehydration, overview ?
tetraprenyl-alpha-curcumene + H2O
-
 Bacillus subtilis 168 (1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol
-
 ?
tetraprenyl-alpha-curcumene + H2O
-
 Bacillus subtilis 168 (1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol the product is further converted by nonenzymatic autoxidation and thermal dehydration, overview ?

Synonyms

Synonyms Comment Organism
sqhC
-
 Bacillus subtilis
tetraprenyl-beta-curcumene cyclase
-
 Bacillus subtilis

General Information

General Information Comment Organism
evolution tetraprenyl-beta-curcumene cyclase shows no sequence homology to any of the known terpene cyclases Bacillus subtilis
metabolism the enzyme is involved in biosynthesis of terpenes of the distinct family of sesquarterpenes, that are mono- and pentacyclic C35 terpenes biosynthesized via the cyclization of C35 isoprenoid, overview Bacillus subtilis