Reference on EC 3.4.24.86 - ADAM 17 endopeptidase and Organism(s) Sus scrofa and UniProt Accession O77636
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Becherer, J.D.; Lambert, M.H.; Andrews, R.C.
The tumor necrosis factor-alpha converting enzyme
Handbook of Experimental Pharmacology, (von der Helm, K. ; Korant, B. C. ; Cheronis, J. C. eds. )
140
235-258
2000
Homo sapiens, Mus musculus, Sus scrofa
-
Xue, C.B.; He, X.; Corbett, R.L.; Roderick, J.; Wasserman, Z.R.; Liu, R.Q.; Jaffee, B.D.; Covington, M.B.; Qian, M.; Trzaskos, J.M.; Newton, R.C.; Magolda, R.L.; Wexler, R.R.; Decicco, C.P.
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release
J. Med. Chem.
44
3351-3354
2001
Homo sapiens, Sus scrofa
Flannery C.R.; Little C.B.; Caterson B.; Hughes C.E.
Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
Matrix Biol.
18
225-237
1999
Sus scrofa (O77636), Sus scrofa
Duan, J.J.; Lu, Z.; Wasserman, Z.R.; Liu, R.; Covington, M.B.; Decicco, C.P.
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme
Bioorg. Med. Chem. Lett.
15
2970-2973
2005
Sus scrofa
Duan, J.J.; Chen, L.; Lu, Z.; Jiang, B.; Asakawa, N.; Sheppeck, J.E.; Liu, R.Q.; Covington, M.B.; Pitts, W.; Kim, S.H.; Decicco, C.P.
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Bioorg. Med. Chem. Lett.
17
266-271
2006
Sus scrofa
Sheppeck, J.E.; Gilmore, J.L.; Yang, A.; Chen, X.; Xue, C.; Roderick, J.; Liu, R.; Covington, M.B.; Decicco, C.P.; Duan, J.J.
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Bioorg. Med. Chem. Lett.
17
1413-1417
2007
Sus scrofa
Chen, X.; Ghavimi, B.; Corbett, R.L.; Xue, C.; Liu, R.; Covington, M.B.; Qian, M.; Vaddi, K.G.; Christ, D.D.; Hartman, K.D.; Ribadeneira, M.D.; Trzaskos, J.M.; Newton, R.C.; Decicco, C.P.; Duan, J.J.
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1 group for the beta-amino hydroxamic acid derived TACE inhibitors
Bioorg. Med. Chem. Lett.
17
1865-1870
2007
Sus scrofa
Ott, G.R.; Asakawa, N.; Liu, R.; Covington, M.B.; Qian, M.; Vaddi, K.; Newton, R.C.; Trzaskos, J.M.; Christ, D.D.; Galya, L.; Scholz, T.; Marshall, W.; Duan, J.J.
alpha,beta-cyclic-beta-Benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
Bioorg. Med. Chem. Lett.
18
1288-1292
2008
Sus scrofa
Duan, J.J.; Chen, L.; Lu, Z.; Xue, C.; Liu, R.; Covington, M.B.; Qian, M.; Wasserman, Z.R.; Vaddi, K.; Christ, D.D.; Trzaskos, J.M.; Newton, R.C.; Decicco, C.P.
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Bioorg. Med. Chem. Lett.
18
241-246
2008
Sus scrofa
Bandarage, U.K.; Wang, T.; Come, J.H.; Perola, E.; Wei, Y.; Rao, B.G.
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones
Bioorg. Med. Chem. Lett.
18
44-48
2008
Sus scrofa
Lu, Z.; Ott, G.R.; Anand, R.; Liu, R.Q.; Covington, M.B.; Vaddi, K.; Qian, M.; Newton, R.C.; Christ, D.D.; Trzaskos, J.; Duan, J.J.
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1 substituents
Bioorg. Med. Chem. Lett.
18
1958-1962
2008
Sus scrofa
Cherney, R.J.; Duan, J.J.; Voss, M.E.; Chen, L.; Wang, L.; Meyer,D.T.; Wasserman, Z.R.; Hardman, K.D.; Liu, R.Q.; Covington, M.B.; Qian, M.; Mandlekar, S.; Christ, D.; Trzaskos, J.M.; Newton, R.C.; Magolda, R.L.; Wexler, R.R.; Decicco, C.P.
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors
J. Med. Chem.
46
1811-1823
2003
Sus scrofa
