Information on EC 3.4.23.B13 - proteinase P15

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The expected taxonomic range for this enzyme is: Avian myeloblastosis-associated virus

EC NUMBER
COMMENTARY hide
3.4.23.B13
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
proteinase P15
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY hide
71892-49-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-Ser-Ala-Pro-Pro-Pro-Pro-Tyr-Val-Gly-Ser-Gly-Leu-Tyr-Pro-Ser + H2O
Ala-Ser-Ala-Pro-Pro-Pro-Pro-Tyr-Val-Gly + Ser-Gly-Leu-Tyr-Pro-Ser
show the reaction diagram
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50%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
-
-
?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Leu + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
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-
-
?
Ala-Thr-His-Gln-Val-Met-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Met + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
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75.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-His-Gln-Val-Met-Pro-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Met + Pro-Val-Arg-Lys-Ala
show the reaction diagram
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52% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Gln-Val-Ser-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Ser + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
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9.4% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Gln-His-Thr + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Gln-His-Thr
show the reaction diagram
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54.2% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Met-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Met-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
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71.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg
show the reaction diagram
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6% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu
show the reaction diagram
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14% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala
show the reaction diagram
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6.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-Phe-Gln-Ala-Tyr-Phe(NO2)-Ala-Gln-Phe-Thr + H2O
Ala-Thr-Phe-Gln-Ala-Tyr + Phe(NO2)-Ala-Gln-Phe-Thr
show the reaction diagram
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12.9% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Ala-Gln-Phe-Thr + H2O
Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Ala-Gln-Phe-Thr
show the reaction diagram
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88.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Cys-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
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-
?
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
show the reaction diagram
ALV Pr76 Gag + H2O
?
show the reaction diagram
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-
?
Cys-Glu-Val-Thr-Gly-Val-Arg-Ala-Asp-Val-His-Leu-Leu-Glu-Gln-Pro + H2O
Cys-Glu-Val-Thr-Gly-Val-Arg-Ala + Asp-Val-His-Leu-Leu-Glu-Gln-Pro
show the reaction diagram
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35% of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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-
?
Gly-Pro-Glu-Pro-Pro-Ala-Val-Ser-Leu-Ala-Met-Thr-Met-Glu-His-Lys + H2O
Gly-Pro-Glu-Pro-Pro-Ala-Val-Ser + Leu-Ala-Met-Thr-Met-Glu-His-Lys
show the reaction diagram
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80%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro + H2O
Gly-Pro-Val-Val-Phe(NO2) + Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
show the reaction diagram
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?
HIV-1 polyprotein + H2O
?
show the reaction diagram
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cleavage of the HIV-1 polyprotein only at concentrations above 0.001 mM. Cleavage products are very similar or identical to that of HIV-1 protease
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?
Leu-Glu-Lys-Ser-His-Cys-Ile-Ala-Glu-Val-Glu-Lys-Asp-Ala-Ile-Pro + H2O
Leu-Glu-Lys-Ser-His-Cys-Ile-Ala + Glu-Val-Glu-Lys-Asp-Ala-Ile-Pro
show the reaction diagram
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50%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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-
?
Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
show the reaction diagram
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20% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu + H2O
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu
show the reaction diagram
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90%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu-Lys + H2O
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu-Lys
show the reaction diagram
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6% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Thr-Gly-Pro-Pro-Val-Val-Ala-Met-Pro-Val-val-Ile-Lys-Thr-Glu-Gly + H2O
Thr-Gly-Pro-Pro-Val-Val-Ala-Met + Pro-Val-Val-Ile-Lys-Thr-Glu-Gly
show the reaction diagram
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10%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
show the reaction diagram
Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala + H2O
Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala
show the reaction diagram
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?
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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cleavage of ALV PR76Gag and HIV-1 polyprotein is stimulated by high salt concentrations
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ala-Thr-His-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-His-Thr-Ala
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Ala-Thr-His-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Lys-Ala
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Arg-Arg-Arg-Met-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Met-Pro
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Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Met-Pro
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Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Met-Pro
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butyloxycarbonyl-Tyr-Val-statine-Ala-statine methyl ester
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Cys-Thr-Asn-Leu-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ile-Ser-Pro-Ile
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Cys-Thr-Asn-Leu-PhePSI[CH2NH]-Pro-Ile-Ser-Pro-Ile
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Gly-Pro-Val-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Ser-Thr-Ala
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His-Pro-His-Leu-Ser-PhePSI[CH2NH]-Met-Ala-Tyr
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His-Ser-Leu-Arg-PhePSI[CH2NH]Phe-Arg-Leu-Pro
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Met-Ser-Leu-Asn-statine-Val-Ala-Lys-Val
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Pro-Ala-Val-statine-Ala-Met-Thr-Met
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IC50 above 1.5 mM, Ki-value above 0.16 mM
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Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Arg-Pro
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Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
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IC50 is above 0.06 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
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IC50: 0.04 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
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Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Arg-Pro
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Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
Pro-Cys-Val-((3S,4S)-4-amino-7-guanidino-3-hydroxyheptanoic acid)-Val-Arg-Pro
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Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
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Pro-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-Phe-Pro
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Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.037 mM
Pro-Pro-Ala-Val-D-Ser-Leu-Ala-Met-Thr-Met
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IC50: above 1.5 mM, Ki-value: above 0.05 mM
Pro-Pro-Ala-Val-Ser-D-Leu-Ala-Met-Thr-Met
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IC50: above 1.5 mM, Ki-value: above 0.06 mM
Pro-Pro-Ala-Val-statine-Ala-Met-Thr-Met
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IC50: above 1.5 mM, Ki-value: above 0.1 mM
Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.009 mM
Pro-Pro-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Gln-Pro-Pro
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Pro-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro-Pro
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Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.0125 mM
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Gly-Leu-Tyr-Pro
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Pro-Pro-Tyr-Val-statine-Gly-Leu-Tyr-Pro
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Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.003 mM
Pro-Thr-Phe-Gln-Ala-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Leu-Arg-Glu-Ala-Pro
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Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Arg-Pro
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Thr-Phe-Cys-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
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Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
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Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
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Thr-Phe-Gln-Ala-PhePSI[CH2-NH]Pro-Leu-Arg-Glu-Ala
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Thr-Phe-Gln-Ala-Phe[CH2-NH]Pro-Leu-Arg-Glu-Ala
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IC50: 1.1 mM
Thr-Phe-[(S-methylcysteine)-Ala-(3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid]-Leu-Arg-Glu-Ala
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Thr-Thr-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.004 - 0.024
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.017
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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pH 6.0, 37°C
0.007 - 0.025
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.007 - 0.009
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.007 - 0.042
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.025 - 0.12
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.052
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala
-
pH 6.0, 37°C
0.013 - 0.031
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
0.007 - 0.082
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.003 - 0.0062
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.0016 - 0.026
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.014
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
pH 6.0, 37°C
0.008
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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pH 6.0, 37°C
0.009
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
pH 6.0, 37°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3 - 11
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
2
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
Avian myeloblastosis-associated virus
-
pH 6.0, 37°C
1 - 11
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.5 - 2.6
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
2 - 4
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
0.2 - 1.5
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
4
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala
Avian myeloblastosis-associated virus
-
pH 6.0, 37°C
3 - 7.1
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
4.9 - 9
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
4.7 - 5
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
6.8 - 11
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
6
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
Avian myeloblastosis-associated virus
-
pH 6.0, 37°C
3
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
Avian myeloblastosis-associated virus
-
pH 6.0, 37°C
5
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
Avian myeloblastosis-associated virus
-
pH 6.0, 37°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00013
Ala-Thr-His-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-His-Thr-Ala
-
pH 6.0, 37°C
0.00016
Ala-Thr-His-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Lys-Ala
-
pH 6.0, 37°C
0.000172
Arg-Arg-Arg-Met-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.0059
Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.0026
Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.00028
butyloxycarbonyl-Tyr-Val-statine-Ala-statine methyl ester
-
pH 6.0, 37°C
0.00518
Cys-Thr-Asn-Leu-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ile-Ser-Pro-Ile
-
-
0.00436
Cys-Thr-Asn-Leu-PhePSI[CH2NH]-Pro-Ile-Ser-Pro-Ile
-
pH 6.0, 37°C
0.00024
Gly-Pro-Val-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Ser-Thr-Ala
-
pH 6.0, 37°C
0.016
His-Pro-His-Leu-Ser-PhePSI[CH2NH]-Met-Ala-Tyr
-
pH 6.0, 37°C
0.09
His-Ser-Leu-Arg-PhePSI[CH2NH]Phe-Arg-Leu-Pro
-
pH 6.0, 37°C
0.02
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
-
pH 6.0, 37°C
0.00003
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
-
pH 6, 37°C
0.0011
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00004
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00039
Pro-Cys-Val--((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00016
Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00025
Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
-
pH 6, 37°C
0.0052
Pro-Pro-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Gln-Pro-Pro
-
pH 6.0, 37°C
0.00312
Pro-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro-Pro
-
pH 6.0, 37°C
0.0002
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
0.000005 - 0.00001
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
0.019
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Gly-Leu-Tyr-Pro
-
pH 6.0, 37°C
0.00095
Pro-Pro-Tyr-Val-statine-Gly-Leu-Tyr-Pro
-
pH 6.0, 37°C
0.00001
Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
0.000065
Pro-Thr-Phe-Gln-Ala-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Leu-Arg-Glu-Ala-Pro
-
pH 6, 37°C
0.00043
Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Arg-Pro
-
pH 6.0, 37°C
0.00157
Thr-Phe-(S-methylcysteine)-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.00032
Thr-Phe-Cys-Ala-[(3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid]-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.00013
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
pH 6.0, 37°C
0.00087
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.0158
Thr-Phe-Gln-Ala-PhePSI[CH2-NH]Pro-Leu-Arg-Glu-Ala
-
pH 6.0, 37°C
0.000026
Thr-Thr-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
pH 6.0, 37°C
additional information
additional information
-
Ki-value for Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met is below 0.01 mM. The Ki-value for Pro-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-Phe-Pro, Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Arg-Pro and Pro-Cys-Val-((3S,4S)-4-amino-7-guanidino-3-hydroxyheptanoic acid)-Val-Arg-Pro are above 0.1 mM: The Ki-value for Met-Ser-Leu-Asn-statine-Val-Ala-Lys-Val is above 0.08 mM
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.5
Pro-Ala-Val-statine-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50 above 1.5 mM, Ki-value above 0.16 mM
-
0.06
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
Avian myeloblastosis-associated virus
-
IC50 is above 0.06 mM
0.04
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
Avian myeloblastosis-associated virus
-
IC50: 0.04 mM
0.06
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
Avian myeloblastosis-associated virus
-
IC50: 0.06 mM
0.037
Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.037 mM
1.5
Pro-Pro-Ala-Val-D-Ser-Leu-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: above 1.5 mM, Ki-value: above 0.05 mM
1.5
Pro-Pro-Ala-Val-Ser-D-Leu-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: above 1.5 mM, Ki-value: above 0.06 mM
1.5
Pro-Pro-Ala-Val-statine-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: above 1.5 mM, Ki-value: above 0.1 mM
0.009
Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.009 mM
0.0125
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.0125 mM
0.0125
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.0125 mM
0.003
Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.003 mM
1.1
Thr-Phe-Gln-Ala-Phe[CH2-NH]Pro-Leu-Arg-Glu-Ala
Avian myeloblastosis-associated virus
-
IC50: 1.1 mM
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.7
-
isoelectric focusing
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 14000, in contrast to gel filtration, ultracentrifugation data show that the enzyme is present in dimeric and multimeric forms, SDS-PAGE
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression of the truncated precursor (Pr25lac-DELTAgag) in Escherichia coli, structurally correct processing
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A100L/V104T/R105P/G106V/S107N