Protein Variants | Comment | Organism |
---|---|---|
A100L/V104T/R105P/G106V/S107N | proteolytic activity of the mutant enzyme is higher than that of the wild-type enzyme. For Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala the parameter turnover-number/Km-value shows a 23fold increase, alteration of the specificity of the mutant enzyme towards that of HIV-1 protease | Avian myeloblastosis-associated virus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.0033 | - |
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.004 | - |
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.0062 | - |
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.007 | - |
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.007 | - |
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.007 | - |
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.013 | - |
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.024 | - |
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.025 | - |
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.025 | - |
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
0.026 | - |
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.042 | - |
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.082 | - |
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.12 | - |
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Avian myeloblastosis-associated virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? | |
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O | - |
Avian myeloblastosis-associated virus | Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
0.5 | - |
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
1.4 | - |
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
1.5 | - |
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
2 | - |
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
2.6 | - |
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
3.1 | - |
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
3.2 | - |
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
3.9 | - |
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
4.3 | - |
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
4.7 | - |
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
4.9 | - |
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | wild-type enzyme | Avian myeloblastosis-associated virus | |
5 | - |
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
6.8 | - |
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
7.1 | - |
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
9 | - |
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus | |
11 | - |
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala | mutant enzyme A100L/V104T/R105P/G106V/S107N | Avian myeloblastosis-associated virus |