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Literature summary for 3.4.23.B13 extracted from

  • Strop, P.; Horejsi, M.; Konvalinka, J.; Skrabana, R.; Velek, J.; Blaha, I.; Cerna, V.; Pichova, I.; Pavlickova, L.; et al.
    Protein-engineered proteinase of myeloblastosis associated virus, an enzyme of high activity and HIV-1 proteinase-like specificity (1991), Adv. Exp. Med. Biol., 306, 515-518.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A100L/V104T/R105P/G106V/S107N proteolytic activity of the mutant enzyme is higher than that of the wild-type enzyme. For Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala the parameter turnover-number/Km-value shows a 23fold increase, alteration of the specificity of the mutant enzyme towards that of HIV-1 protease Avian myeloblastosis-associated virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.0033
-
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.004
-
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.0062
-
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.007
-
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.007
-
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.007
-
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.013
-
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.024
-
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.025
-
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.025
-
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
0.026
-
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.042
-
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.082
-
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.12
-
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus

Organism

Organism UniProt Comment Textmining
Avian myeloblastosis-associated virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
Avian myeloblastosis-associated virus Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.2
-
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
0.5
-
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
1.4
-
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
1.5
-
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
2
-
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
2.6
-
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
3.1
-
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
3.2
-
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
3.9
-
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
4.3
-
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
4.7
-
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
4.9
-
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala wild-type enzyme Avian myeloblastosis-associated virus
5
-
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
6.8
-
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
7.1
-
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
9
-
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus
11
-
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala mutant enzyme A100L/V104T/R105P/G106V/S107N Avian myeloblastosis-associated virus