Reference on EC 3.4.11.20 - aminopeptidase Ey and Organism(s) Plasmodium falciparum and UniProt Accession Q8IL11
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Flipo, M.; Beghyn, T.; Leroux, V.; Florent, I.; Deprez, B.P.; Deprez-Poulain, R.F.
Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents
J. Med. Chem.
50
1322-1334
2007
Plasmodium falciparum, Plasmodium falciparum FcB1
Ragheb, D.; Dalal, S.; Bompiani, K.M.; Ray, W.K.; Klemba, M.
Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism
J. Biol. Chem.
286
27255-27265
2011
Plasmodium falciparum (Q8IEK1), Plasmodium falciparum
Velmourougane, G.; Harbut, M.B.; Dalal, S.; McGowan, S.; Oellig, C.A.; Meinhardt, N.; Whisstock, J.C.; Klemba, M.; Greenbaum, D.C.
Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase
J. Med. Chem.
54
1655-1666
2011
Plasmodium falciparum
Azimzadeh, O.; Sow, C.; Geze, M.; Nyalwidhe, J.; Florent, I.
Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole
Malar. J.
9
189
2010
Plasmodium falciparum (O96935), Plasmodium falciparum
McGowan, S.; Oellig, C.A.; Birru, W.A.; Caradoc-Davies, T.T.; Stack, C.M.; Lowther, J.; Skinner-Adams, T.; Mucha, A.; Kafarski, P.; Grembecka, J.; Trenholme, K.R.; Buckle, A.M.; Gardiner, D.L.; Dalton, J.P.; Whisstock, J.C.
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Proc. Natl. Acad. Sci. USA
107
2449-2454
2010
Plasmodium falciparum (Q8IL11), Plasmodium falciparum
Harbut, M.B.; Velmourougane, G.; Dalal, S.; Reiss, G.; Whisstock, J.C.; Onder, O.; Brisson, D.; McGowan, S.; Klemba, M.; Greenbaum, D.C.
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Proc. Natl. Acad. Sci. USA
108
E526-E534
2011
Plasmodium falciparum, Plasmodium falciparum (Q8IL11)
Mistry, S.N.; Drinkwater, N.; Ruggeri, C.; Sivaraman, K.K.; Loganathan, S.; Fletcher, S.; Drag, M.; Paiardini, A.; Avery, V.M.; Scammells, P.J.; McGowan, S.
Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors
J. Med. Chem.
57
9168-9183
2014
Plasmodium falciparum (O96935), Plasmodium falciparum (Q8IL11), Plasmodium falciparum, Plasmodium falciparum isolate FcB1/Columbia (O96935)
Dalal, S.; Ragheb, D.R.; Klemba, M.
Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum
Mol. Biochem. Parasitol.
183
70-77
2012
Plasmodium falciparum
Gonzalez-Bacerio, J.; Osuna, J.; Ponce, A.; Fando, R.; Figarella, K.; Mendez, Y.; Charli, J.L.; Chavez, M.D.
High-level expression in Escherichia coli, purification and kinetic characterization of Plasmodium falciparum M1-aminopeptidase
Protein Expr. Purif.
104C
103-114
2014
Plasmodium falciparum (Q8IEK1)
Drinkwater, N.; Bamert, R.S.; Kannan Sivaraman, K.; Paiardini, A.; McGowan, S.
X-ray crystal structures of an orally available aminopeptidase inhibitor, tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17
Proteins
83
789-795
2015
Plasmodium falciparum (O96935), Plasmodium falciparum (Q8IL11), Plasmodium falciparum, Plasmodium falciparum isolate FcB1/Columbia (O96935)
