Reference on EC 3.1.3.16 - protein-serine/threonine phosphatase and Organism(s) Homo sapiens and UniProt Accession Q8WVY7
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takeda, M.; Usui, H.; Imazu, M.; Imanoka, T.; Kinohara, N.; Tsukamoto, H.; Maeta, K.
The interaction and function of subunits in protein phosphatase 2A from pig heart and human erythrocyte
Adv. Protein Phosphatases
1
215-233
1985
Homo sapiens, Sus scrofa
-
Usui, H.; Imazu, M.; Maeta, K.; Tsukamoto, H.; Azuma, K.; Takeda, M.
Three distinct forms of type 2A protein phosphatase in human erythrocyte cytosol
J. Biol. Chem.
263
3752-3761
1988
Homo sapiens
Kamibayashi, C.; Lickteig, R.L.; Estes, R.; Walter, G.; Mumby, M.C.
Expression of a subunit of protein phosphatase 2A and characterization of its interaction with the catalytic and regulatory subunits
J. Biol. Chem.
267
21864-21872
1992
Homo sapiens
Marley, A.E.; Sullivan, J.E.; Carling, D.; Abbott, W.M.; Smith, G.J.; Taylor, I.W.F.; Carey, F.; Beri, R.K.
Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C
Biochem. J.
320
801-806
1996
Homo sapiens
-
Nagase, T.; Murakami, T.; Nozaki, H.; Inoue, R.; Nishito, Y.; Tanabe, O.; Usui, H.; Takeda, M.
Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B subunit
J. Biochem.
122
178-187
1997
Homo sapiens, Rattus norvegicus
Huang, X.; Honkanen, R.E.
Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)
J. Biol. Chem.
273
1462-1468
1998
Homo sapiens
Hanlon, N.; Barford, D.
Purification and crystallization of the CDL-associated protein phosphatase KAP expressed in Escherichia coli
Protein Sci.
7
508-511
1998
Homo sapiens
Das, A.K.; Helps, N.R.; Cohen, P.T.; Barford, D.
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution
EMBO J.
15
6798-6809
1996
Homo sapiens
Barford, D.; Keller, J.C.; Flint, A.J.; Tonks, N.K.
Purification and crystallization of the catalytic domain of human protein tyrosine phosphatase 1B expressed in Escherichia coli
J. Mol. Biol.
239
726-730
1994
Homo sapiens
Fan, G.Y.; Maldonado, F.; Zhang, Y.; Kincaid, R.; Ellisman, M.H.; Gastinel, L.N.
In vivo calcineurin crystals formed using the baculovirus expression system
Microsc. Res. Tech.
34
77-86
1996
Homo sapiens, Neurospora crassa
Zhao, R.; Qi, Y.; Zhao, Z.J.
FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain
Biochem. Biophys. Res. Commun.
270
222-229
2000
Homo sapiens
Janssens, V.; Goris, J.
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signaling
Biochem. J.
353
417-439
2001
Homo sapiens
Myles, T.; Schmidt, K.; Evans, D.R.H.; Cron, P.; Hemmings, B.A.
Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells
Biochem. J.
357
225-232
2001
Homo sapiens
Zhou, J.; Pham, H.T.; Ruediger, R.; Walter, G.
Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution
Biochem. J.
369
387-398
2003
Homo sapiens
Swiatek, W.; Sugajska, E.; Lankiewicz, L.; Hemmings, B.A.; Zolnierowicz, S.
Biochemical characterization of recombinant subunits of type 2A protein phosphatase overexpressed in Pichia pastoris
Eur. J. Biochem.
267
5209-5216
2000
Oryctolagus cuniculus, Homo sapiens
Johnson, T.R.; Biggs, J.R.; Winbourn, S.E.; Kraft, A.S.
Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain
J. Biol. Chem.
275
31755-31762
2000
Homo sapiens, Mus musculus
Douglas, P.; Moorhead, G.B.G.; Ye, R.; Lees-Miller, S.P.
Protein phosphatases regulate DNA-dependent protein kinase activity
J. Biol. Chem.
276
18992-18998
2001
Homo sapiens
Hallaway, B.J.; O'Kane, D.J.
Chemiluminescence assay of serum alkaline phosphatase and phosphoprotein phosphatases
Methods Enzymol.
305
391-401
2000
Homo sapiens
Cheng, L.Y.; Wang, J.Z.; Gong, C.X.; Pei, J.J.; Zaidi, T.; Grundke-Iqbal, I.; Iqbal, K.
Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities
Neurochem. Res.
26
425-438
2001
Homo sapiens
Cohen, P.T.W
Overview of protein serine/threonine phosphatases
Topics in Current Genetics (Arino, J. , Alexander, D. R. Eds. ) Springer
5
1-20
2004
Homo sapiens
-
Zeke, T.; Morrice, N.; Vazquez-Martin, C.; Cohen, P.T.
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
Biochem. J.
385
45-56
2005
Homo sapiens
Yamaguchi, H.; Minopoli, G.; Demidov, O.N.; Chatterjee, D.K.; Anderson, C.W.; Durell, S.R.; Appella, E.
Substrate specificity of the human protein phosphatase 2Cdelta, Wip1
Biochemistry
44
5285-5294
2005
Homo sapiens
Inostroza, J.; Saenz, L.; Calaf, G.; Cabello, G.; Parra, E.
Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity
Biol. Res.
38
163-178
2005
Homo sapiens
Gallego, M.; Virshup, D.M.
Protein serine/threonine phosphatases: life, death, and sleeping
Curr. Opin. Cell Biol.
17
197-202
2005
Drosophila melanogaster, Lingulodinium polyedra, Homo sapiens, Mus musculus, Neurospora crassa
Yang, J.; Roe, S.M.; Cliff, M.J.; Williams, M.A.; Ladbury, J.E.; Cohen, P.T.; Barford, D.
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
EMBO J.
24
1-10
2005
Homo sapiens
Haneda, M.; Kojima, E.; Nishikimi, A.; Hasegawa, T.; Nakashima, I.; Isobe, K.
Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53
FEBS Lett.
567
171-174
2004
Homo sapiens, Mus musculus
Cohen, P.T.; Philp, A.; Vazquez-Martin, C.
Protein phosphatase 4 - from obscurity to vital functions
FEBS Lett.
579
3278-3286
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
Zhang, X.; Ozawa, Y.; Lee, H.; Wen, Y.D.; Tan, T.H.; Wadzinski, B.E.; Seto, E.
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4
Genes Dev.
19
827-839
2005
Homo sapiens
Harvey, B.P.; Banga, S.S.; Ozer, H.L.
Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts
J. Biol. Chem.
279
24889-24898
2004
Homo sapiens
Anderson, K.A.; Noeldner, P.K.; Reece, K.; Wadzinski, B.E.; Means, A.R.
Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
J. Biol. Chem.
279
31708-31716
2004
Homo sapiens
Swingle, M.R.; Honkanen, R.E.; Ciszak, E.M.
Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5
J. Biol. Chem.
279
33992-33999
2004
Homo sapiens (P36873), Homo sapiens
Mihindukulasuriya, K.A.; Zhou, G.; Qin, J.; Tan, T.H.
Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation
J. Biol. Chem.
279
46588-46594
2004
Homo sapiens
Zhou, G.; Golden, T.; Aragon, I.V.; Honkanen, R.E.
Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade
J. Biol. Chem.
279
46595-46605
2004
Homo sapiens
Gibbons, J.A.; Weiser, D.C.; Shenolikar, S.
Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators
J. Biol. Chem.
280
15903-15911
2005
Homo sapiens
Vijayan, K.V.; Liu, Y.; Sun, W.; Ito, M.; Bray, P.F.
The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases
J. Biol. Chem.
280
21756-21762
2005
Homo sapiens
Thelin, W.R.; Kesimer, M.; Tarran, R.; Kreda, S.M.; Grubb, B.R.; Sheehan, J.K.; Stutts, M.J.; Milgram, S.L.
The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A
J. Biol. Chem.
280
41512-41520
2005
Homo sapiens
Adams, D.G.; Coffee, R.L., Jr.; Zhang, H.; Pelech, S.; Strack, S.; Wadzinski, B.E.
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
J. Biol. Chem.
280
42644-42654
2005
Homo sapiens
Takahashi, K.; Nakajima, E.; Suzuki, K.
Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1
J. Cell. Physiol.
206
814-820
2006
Homo sapiens
Jin, F.; Ji, C.; Liu, L.; Dai, J.; Gu, S.; Sun, X.; Xie, Y.; Mao, Y.
Molecular cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon)
Mol. Biol. Rep.
31
197-202
2004
Homo sapiens (Q5SGD2), Homo sapiens
Liu, L.; Zhang, J.; Yuan, J.; Dang, Y.; Yang, C.; Chen, X.; Xu, J.; Yu, L.
Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis
Mol. Biol. Rep.
32
41-45
2005
Homo sapiens (Q96LZ3), Homo sapiens
Arnold, H.K.; Sears, R.C.
Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation
Mol. Cell. Biol.
26
2832-2844
2006
Homo sapiens
Crossthwaite, A.J.; Ciruela, A.; Rayner, T.F.; Cooper, D.M.
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A
Mol. Pharmacol.
69
608-617
2006
Homo sapiens, Mus musculus
Chung, H.Y.; Cha, B.; Kim, H.
Inhibition of serine-threonine protein phosphatases in monocyte chemoattractant protein-1 expression in Helicobacter pylori-stimulated gastric epithelial cells
Ann. N. Y. Acad. Sci.
1095
220-227
2007
Homo sapiens
Escargueil, A.E.; Larsen, A.K.
Mitosis-specific MPM-2 phosphorylation of DNA topoisomerase IIalpha is regulated directly by protein phosphatase 2A
Biochem. J.
403
235-242
2007
Homo sapiens
Karlsson, M.; Mandl, M.; Keyse, S.M.
Spatio-temporal regulation of mitogen-activated protein kinase (MAPK) signalling by protein phosphatases
Biochem. Soc. Trans.
34
842-845
2006
Homo sapiens
Codreanu, S.G.; Adams, D.G.; Dawson, E.S.; Wadzinski, B.E.; Liebler, D.C.
Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage
Biochemistry
45
10020-10029
2006
Homo sapiens
Yamaguchi, H.; Durell, S.R.; Feng, H.; Bai, Y.; Anderson, C.W.; Appella, E.
Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1
Biochemistry
45
13193-13202
2006
Homo sapiens
Xie, X.J.; Xue, C.Z.; Huang, W.; Yu, D.Y.; Wei, Q.
The beta12-beta13 loop is a key regulatory element for the activity and properties of the catalytic domain of protein phosphatase 1 and 2B
Biol. Chem.
387
1461-1467
2006
Homo sapiens
Kochinyan, S.; Sun, L.; Ghosh, I.; Barshevsky, T.; Xu, J.; Xu, M.Q.
Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases
Biotechniques
42
63-69
2007
Oryctolagus cuniculus, Homo sapiens
Miglietta, A.; Bozzo, F.; Gabriel, L.; Bocca, C.; Canuto, R.A.
Extracellular signal-regulated kinase 1/2 and protein phosphatase 2A are involved in the antiproliferative activity of conjugated linoleic acid in MCF-7 cells
Br. J. Nutr.
96
22-27
2006
Homo sapiens
Bos, C.L.; Diks, S.H.; Hardwick, J.C.; Walburg, K.V.; Peppelenbosch, M.P.; Richel, D.J.
Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity
Carcinogenesis
27
2371-2382
2006
Homo sapiens
Avci, C.B.; Sahin, F.; Gunduz, C.; Selvi, N.; Aydin, H.H.; Oktem, G.; Topcuoglu, N.; Saydam, G.
Protein phosphatase 2A (PP2A) has a potential role in CAPE-induced apoptosis of CCRF-CEM cells via effecting human telomerase reverse transcriptase activity
Hematology
12
519-525
2007
Homo sapiens
Dai, J.; Zhang, J.; Sun, Y.; Wu, Q.; Sun, L.; Ji, C.; Gu, S.; Feng, C.; Xie, Y.; Mao, Y.
Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa
Int. J. Mol. Med.
17
1117-1123
2006
Homo sapiens (Q8N3J5), Homo sapiens
Kajino, T.; Ren, H.; Iemura, S.; Natsume, T.; Stefansson, B.; Brautigan, D.L.; Matsumoto, K.; Ninomiya-Tsuji, J.
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway
J. Biol. Chem.
281
39891-39896
2006
Homo sapiens
Kitatani, K.; Idkowiak-Baldys, J.; Hannun, Y.A.
Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641
J. Biol. Chem.
282
20647-20656
2007
Homo sapiens
Jang, Y.J.; Ji, J.H.; Choi, Y.C.; Ryu, C.J.; Ko, S.Y.
Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A
J. Biol. Chem.
282
2473-2482
2007
Homo sapiens
Ricotta, D.; Hansen, J.; Preiss, C.; Teichert, D.; Hoening, S.
Characterization of a protein phosphatase 2A holoenzyme (PP2A) that dephosphorylates the clathrin adaptors AP-1 and AP-2
J. Biol. Chem.
283
5510-551
2008
Homo sapiens
Tao, G.Z.; Toivola, D.M.; Zhou, Q.; Strnad, P.; Xu, B.; Michie, S.A.; Omary, M.B.
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner
J. Cell Sci.
119
1425-1432
2006
Homo sapiens
Rogers, J.P.; Beuscher, A.E.; Flajolet, M.; McAvoy, T.; Nairn, A.C.; Olson, A.J.; Greengard, P.
Discovery of protein phosphatase 2C inhibitors by virtual screening
J. Med. Chem.
49
1658-1667
2006
Homo sapiens (P35813)
Liu, C.W.; Wang, R.H.; Berndt, N.
Protein phosphatase 1alpha activity prevents oncogenic transformation
Mol. Carcinog.
45
648-656
2006
Homo sapiens, Mus musculus
Prickett, T.D.; Brautigan, D.L.
Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3
Mol. Cell. Biol.
27
4217-4227
2007
Homo sapiens
Shouse, G.P.; Cai, X.; Liu, X.
Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A
Mol. Cell. Biol.
28
448-456
2008
Homo sapiens
Chen, Y.; Xu, Y.; Bao, Q.; Xing, Y.; Li, Z.; Lin, Z.; Stock, J.B.; Jeffrey, P.D.; Shi, Y.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
Nat. Struct. Mol. Biol.
14
527-534
2007
Homo sapiens
Cho, U.S.; Xu, W.
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
Nature
445
53-57
2007
Homo sapiens
Eichhorn, P.J.; Creyghton, M.P.; Wilhelmsen, K.; van Dam, H.; Bernards, R.
A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC
PLoS Genet.
3
e218
2007
Homo sapiens
Kuroda, F.; Moss, J.; Vaughan, M.
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma
Proc. Natl. Acad. Sci. USA
104
3201-3206
2007
Homo sapiens
Shah, B.H.; Catt, K.J.
Protein phosphatase 5 as a negative key regulator of Raf-1 activation
Trends Endocrinol. Metab.
17
382-384
2006
Homo sapiens
Stefansson, B.; Ohama, T.; Daugherty, A.E.; Brautigan, D.L.
Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains
Biochemistry
47
1442-1451
2008
Homo sapiens
Golden, T.; Aragon, I.V.; Rutland, B.; Tucker, J.A.; Shevde, L.A.; Samant, R.S.; Zhou, G.; Amable, L.; Skarra, D.; Honkanen, R.E.
Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer
Biochim. Biophys. Acta
1782
259-270
2008
Homo sapiens
Mourtada-Maarabouni, M.; Williams, G.T.
Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells
Biochim. Biophys. Acta
1783
1490-1502
2008
Homo sapiens
Eichhorn, P.J.; Creyghton, M.P.; Bernards, R.
Protein phosphatase 2A regulatory subunits and cancer
Biochim. Biophys. Acta
1795
1-15
2009
Homo sapiens
Wang, K.; Song, Y.; Chen, D.B.; Zheng, J.
Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells
Biol. Reprod.
79
704-710
2008
Homo sapiens
Deng, X.; Gao, F.; May, W.S.
Protein phosphatase 2A inactivates Bcl2s antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
Blood
113
422-428
2009
Homo sapiens
Golden, T.; Swingle, M.; Honkanen, R.E.
The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer
Cancer Metastasis Rev.
27
169-178
2008
Homo sapiens (P53041), Homo sapiens
Lu, G.; Wang, Y.
Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family
Clin. Exp. Pharmacol. Physiol.
35
107-112
2008
Homo sapiens
Yi, K.D.; Simpkins, J.W.
Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
Endocrinology
149
5235-5243
2008
Homo sapiens, Rattus norvegicus
Brandt, N.; Franke, K.; Johannes, S.; Buck, F.; Harder, S.; Hassel, B.; Nitsch, R.; Schumacher, S.
B56beta, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching
FASEB J.
22
2521-2533
2008
Homo sapiens
Pulido, R.; Hooft van Huijsduijnen, R.
Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease
FEBS J.
275
848-866
2008
Homo sapiens (O95248), Homo sapiens (O95278), Homo sapiens (P28562), Homo sapiens (P60484), Homo sapiens (Q05923), Homo sapiens (Q16828), Homo sapiens (Q93096), Homo sapiens (Q9BV47), Homo sapiens (Q9Y6W6)
Chen, L.; Dong, W.; Zou, T.; Ouyang, L.; He, G.; Liu, Y.; Qi, Y.
Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6
FEBS Lett.
582
2843-2849
2008
Homo sapiens
Sahin, F.; Celik, H.A.; Aydin, H.H.; Oktem, G.; Omay, S.B.; Saydam, G.
The interaction between taxoids and serine/threonine protein phosphatase activities during taxan-induced apoptosis of HL 60 leukemic cells
Hematology
13
215-223
2008
Homo sapiens
Xie, X.J.; Huang, W.; Xue, C.Z.; Wei, Q.
The nonconserved N-terminus of protein phosphatase 2B confers its properties to protein phosphatase 1
IUBMB Life
61
178-183
2009
Homo sapiens
McWhirter, C.; Lund, E.A.; Tanifum, E.A.; Feng, G.; Sheikh, Q.I.; Hengge, A.C.; Williams, N.H.
Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme
J. Am. Chem. Soc.
130
13673-13682
2008
Homo sapiens
Gushiken, F.C.; Patel, V.; Liu, Y.; Pradhan, S.; Bergeron, A.L.; Peng, Y.; Vijayan, K.V.
Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling
J. Biol. Chem.
283
12862-12869
2008
Homo sapiens
Kang, Y.; Lee, J.H.; Hoan, N.N.; Sohn, H.M.; Chang, I.Y.; You, H.J.
Protein phosphatase 5 regulates the function of 53BP1 after NCS-induced DNA damage
J. Biol. Chem.
284
9845-9853
2009
Homo sapiens
Kelker, M.S.; Page, R.; Peti, W.
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
J. Mol. Biol.
385
11-21
2009
Homo sapiens (P62136)
Wang, N.; Leung, H.T.; Pak, W.L.; Carl, Y.T.; Wadzinski, B.E.; Shieh, B.H.
Role of protein phosphatase 2A in regulating the visual signaling in Drosophila
J. Neurosci.
28
1444-1451
2008
Drosophila melanogaster, Homo sapiens
Xu, Y.; Chen, Y.; Zhang, P.; Jeffrey, P.D.; Shi, Y.
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation
Mol. Cell
31
873-885
2008
Homo sapiens
Li, H.; Okamoto, K.; Peart, M.J.; Prives, C.
Lysine-independent turnover of cyclin G1 can be stabilized by Balpha subunits of protein phosphatase 2A
Mol. Cell. Biol.
29
919-928
2009
Homo sapiens
Martin, M.; Potente, M.; Janssens, V.; Vertommen, D.; Twizere, J.C.; Rider, M.H.; Goris, J.; Dimmeler, S.; Kettmann, R.; Dequiedt, F.
Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis
Proc. Natl. Acad. Sci. USA
105
4727-4732
2008
Homo sapiens
Wang, B.; Zhang, P.; Wei, Q.
Recent progress on the structure of Ser/Thr protein phosphatases
Sci. China C Life Sci.
51
487-494
2008
Homo sapiens
Huang, H.S.; Lee, E.Y.
Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response
J. Biol. Chem.
283
18135-18146
2008
Homo sapiens
Ryan, K.; Khleborodova, A.; Pan, J.; Ryan, X.P.
Small molecule activators of pre-mRNA 3 cleavage
RNA
15
483-492
2009
Homo sapiens
Volpe, G.; Cotroneo, E.; Moscone, D.; Croci, L.; Cozzi, L.; Ciccaglioni, G.; Palleschi, G.
A bienzyme electrochemical probe for flow injection analysis of okadaic acid based on protein phosphatase-2A inhibition: an optimization study
Anal. Biochem.
385
50-56
2009
Homo sapiens
Fortwendel, J.R.; Juvvadi, P.R.; Pinchai, N.; Perfect, B.Z.; Alspaugh, J.A.; Perfect, J.R.; Steinbach, W.J.
Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus
Antimicrob. Agents Chemother.
53
476-482
2009
Homo sapiens
Thaci, D.; Salgo, R.
Malignancy concerns of topical calcineurin inhibitors for atopic dermatitis: facts and controversies
Clin. Dermatol.
28
52-56
2010
Homo sapiens
Chen, G.; Zhou, X.; Nicolaou, P.; Rodriguez, P.; Song, G.; Mitton, B.; Pathak, A.; Zachariah, A.; Fan, G.C.; Dorn, G.W.; Kranias, E.G.
A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation
FASEB J.
22
1790-1796
2008
Homo sapiens
Juhasz, T.; Matta, C.; Veress, G.; Nagy, G.; Szijgyarto, Z.; Molnar, Z.; Fodor, J.; Zakany, R.; Gergely, P.
Inhibition of calcineurin by cyclosporine A exerts multiple effects on human melanoma cell lines HT168 and WM35
Int. J. Oncol.
34
995-1003
2009
Homo sapiens
Tanuma, N.; Kim, S.E.; Beullens, M.; Tsubaki, Y.; Mitsuhashi, S.; Nomura, M.; Kawamura, T.; Isono, K.; Koseki, H.; Sato, M.; Bollen, M.; Kikuchi, K.; Shima, H.
Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)
J. Biol. Chem.
283
35805-35814
2008
Homo sapiens
Eto, M.
Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors
J. Biol. Chem.
284
35273-35277
2009
Homo sapiens
Kilili, G.K.; Kyriakis, J.M.
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation
J. Biol. Chem.
285
15076-15087
2010
Homo sapiens, Mus musculus
Erdmann, F.; Weiwad, M.; Kilka, S.; Karanik, M.; Paetzel, M.; Baumgrass, R.; Liebscher, J.; Fischer, G.
The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells
J. Biol. Chem.
285
1888-1898
2010
Homo sapiens
Smit, N.P.; Van Rossum, H.H.; Romijn, F.P.; Sellar, K.J.; Breetveld, M.; Gibbs, S.; Van Pelt, J.
Calcineurin activity and inhibition in skin and (epi)dermal cell cultures
J. Invest. Dermatol.
128
1686-1690
2008
Homo sapiens
Nicolaou, P.; Hajjar, R.J.; Kranias, E.G.
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology
J. Mol. Cell. Cardiol.
47
365-371
2009
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Tumlin, J.A.; Roberts, B.R.; Kokko, K.E.; El Minshawy, O.; Gooch, J.L.
T-cell receptor-stimulated calcineurin activity is inhibited in isolated T cells from transplant patients
J. Pharmacol. Exp. Ther.
330
602-607
2009
Homo sapiens
Nagane, Y.; Suzuki, S.; Suzuki, N.; Utsugisawa, K.
Factors associated with response to calcineurin inhibitors in myasthenia gravis
Muscle Nerve
41
212-218
2010
Homo sapiens
Baek, K.H.; Zaslavsky, A.; Lynch, R.C.; Britt, C.; Okada, Y.; Siarey, R.J.; Lensch, M.W.; Park, I.H.; Yoon, S.S.; Minami, T.; Korenberg, J.R.; Folkman, J.; Daley, G.Q.; Aird, W.C.; Galdzicki, Z.; Ryeom, S.
Downs syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
Nature
459
1126-1130
2009
Homo sapiens, Mus musculus
Baczkowska, T.; Durlik, M.
Calcineurin inhibitor sparing immunosuppressive regimens in kidney allograft recipients
Pol. Arch. Med. Wewn.
119
318-325
2009
Homo sapiens
Martinez-Martinez, S.; Genesca, L.; Rodriguez, A.; Raya, A.; Salichs, E.; Were, F.; Lopez-Maderuelo, M.D.; Redondo, J.M.; de la Luna, S.
The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators
Proc. Natl. Acad. Sci. USA
106
6117-6122
2009
Homo sapiens
Rubiolo, J.A.; Lopez-Alonso, H.; Alfonso, A.; Vega, F.V.; Vieytes, M.R.; Botana, L.M.
Characterization and activity determination of the human protein phosphatase 2A catalytic subunit alpha expressed in insect larvae
Appl. Biochem. Biotechnol.
167
918-928
2012
Homo sapiens (P67775)
De Wever, V.; Nasa, I.; Chamousset, D.; Lloyd, D.; Nimick, M.; Xu, H.; Trinkle-Mulcahy, L.; Moorhead, G.B.
The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif
Biochem. Biophys. Res. Commun.
453
432-437
2014
Homo sapiens
Zhang, M.; Yogesha, S.D.; Mayfield, J.E.; Gill, G.N.; Zhang, Y.
Viewing serine/threonine protein phosphatases through the eyes of drug designers
FEBS J.
280
4739-4760
2013
Homo sapiens (P36873), Bos taurus (P48452)
Peti, W.; Nairn, A.C.; Page, R.
Structural basis for protein phosphatase 1 regulation and specificity
FEBS J.
280
596-611
2013
Homo sapiens (P62136)
Sents, W.; Ivanova, E.; Lambrecht, C.; Haesen, D.; Janssens, V.
The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity
FEBS J.
280
644-661
2013
Homo sapiens
Amsailale, R.; Beyaert, M.; Smal, C.; Janssens, V.; Van Den Neste, E.; Bontemps, F.
Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation
FEBS Lett.
588
727-732
2014
Homo sapiens
Kasa, A.; Czikora, I.; Verin, A.D.; Gergely, P.; Csortos, C.
Protein phosphatase 2A activity is required for functional adherent junctions in endothelial cells
Microvasc. Res.
89
86-94
2013
Homo sapiens
Gregorio, L.K.; Esteves, S.L.; Fardilha, M.
Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins
Transl. Res.
164
366-391
2014
Homo sapiens (P36873), Homo sapiens (P62136), Homo sapiens (P62140)
Wilkins, J.; McConnell, C.; Tipton, P.; Hannink, M.
A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5
J. Biol. Chem.
289
25137-25148
2014
Homo sapiens (Q96HS1)
Hengge, A.C.
Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases
Biochim. Biophys. Acta
1854
1768-1775
2015
Homo sapiens (P51452)
Peti, W.; Page, R.
Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable Achieving specificity by targeting substrate and regulatory protein interaction sites
Bioorg. Med. Chem.
23
2781-2785
2015
Homo sapiens (P62136), Homo sapiens (Q08209)
Zhi, X.; Zhang, H.; He, C.; Wei, Y.; Bian, L.; Li, G.
Serine/threonine protein phosphatase-5 accelerates cell growth and migration in human glioma
Cell. Mol. Neurobiol.
35
669-677
2015
Homo sapiens (P53041), Homo sapiens
Li, H.; Yang, D.; Ning, S.; Xu, Y.; Yang, F.; Yin, R.; Feng, T.; Han, S.; Guo, L.; Zhang, P.; Qu, W.; Guo, R.; Song, C.; Xiao, P.; Zhou, C.; Xu, Z.; Sun, J.P.; Yu, X.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
FASEB J.
32
73-82
2018
Homo sapiens (Q05209)
Chen, Z.; Dempsey, D.R.; Thomas, S.N.; Hayward, D.; Bolduc, D.M.; Cole, P.A.
Molecular features of phosphatase and tensin homolog (PTEN) regulation by C-terminal phosphorylation
J. Biol. Chem.
291
14160-14169
2016
Homo sapiens (P60484)
Heijman, J.; Ghezelbash, S.; Wehrens, X.H.T.; Dobrev, D.
Serine/threonine phosphatases in atrial fibrillation
J. Mol. Cell. Cardiol.
103
110-120
2017
Homo sapiens (P62136), Homo sapiens (P67775), Homo sapiens (Q08209)
Hoffman, A.; Taleski, G.; Sontag, E.
The protein serine/threonine phosphatases PP2A, PP1 and calcineurin A triple threat in the regulation of the neuronal cytoskeleton
Mol. Cell. Neurosci.
84
119-131
2017
Homo sapiens (P62136), Homo sapiens (P67775), Homo sapiens (Q08209)
