Reference on EC 2.7.8.24 - phosphatidylcholine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
De Rudder, K.E.E.; Sohlenkamp, C.; Geiger, O.
Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase
J. Biol. Chem.
274
20011-20016
1999
Sinorhizobium meliloti
Sohlenkamp, C.; de Rudder, K.E.E.; Rhrs, V.; Lopez-Lara, I.M.; Geiger, O.
Cloning and characterization of the gene for phosphatidylcholine synthase
J. Biol. Chem.
275
18919-18925
2000
BRENDA: Sinorhizobium meliloti (Q9KJY8), Sinorhizobium meliloti
Textmining: Borrelia, Escherichia coli, Sinorhizobium
Lee, S.; Moon, J.S.; Ko, T.S.; Petros, D.; Goldsbrough, P.B.; Korban, S.S.
Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress
Plant Physiol.
131
656-663
2003
Arabidopsis
Sauge-Merle, S.; Cuine, S.; Carrier, P.; Lecomte-Pradines, C.; Luu, D.T.; Peltier, G.
Enhanced toxic metal accumulation in engineered bacterial cells expressing Arabidopsis thaliana phytochelatin synthase
Appl. Environ. Microbiol.
69
490-494
2003
Arabidopsis thaliana (Q9S7Z3), Arabidopsis thaliana, Escherichia coli, yeasts
Vatamaniuk, O.K.; Bucher, E.A.; Ward, J.T.; Rea, P.A.
A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans
J. Biol. Chem.
276
20817-20820
2001
Caenorhabditis elegans (G5ECE4), Caenorhabditis elegans, Metazoa, Fungi, Nematoda
Wilderman, P.J.; Vasil, A.I.; Martin, W.E.; Murphy, R.C.; Vasil, M.L.
Pseudomonas aeruginosa synthesizes phosphatidylcholine by use of the phosphatidylcholine synthase pathway
J. Bacteriol.
184
4792-4799
2002
BRENDA: Pseudomonas aeruginosa
Textmining: Bacteria
Martinez-Morales, F.; Schobert, M.; Lopez-Lara, I.M.; Geiger, O.
Pathways for phosphatidylcholine biosynthesis in bacteria
Microbiology
149
3461-3471
2003
BRENDA: Agrobacterium tumefaciens, Borreliella burgdorferi, Bradyrhizobium japonicum, Brucella melitensis (D0B707), Brucella melitensis, Legionella pneumophila, Mesorhizobium loti, Pseudomonas aeruginosa, Rhizobium leguminosarum, Sinorhizobium meliloti
Textmining: Bacteria
Wang, X.G.; Scagliotti, J.P.; Hu, L.T.
Phospholipid synthesis in Borrelia burgdorferi: BB0249 and BB0721 encode functional phosphatidylcholine synthase and phosphatidylglycerolphosphate synthase proteins
Microbiology
150
391-397
2004
BRENDA: Borreliella burgdorferi (O51265), Borreliella burgdorferi
Textmining: Sinorhizobium meliloti, Bacteria, Escherichia coli, Transformation
Tsuji, N.; Nishikori, S.; Iwabe, O.; Matsumoto, S.; Shiraki, K.; Miyasaka, H.; Takagi, M.; Miyamoto, K.; Hirata, K.
Comparative analysis of the two-step reaction catalyzed by prokaryotic and eukaryotic phytochelatin synthase by an ion-pair liquid chromatography assay
Planta
222
181-191
2005
Nostoc, eukaryota, Arabidopsis
Wessel, M.; Kluesener, S.; Goedeke, J.; Fritz, C.; Hacker, S.; Narberhaus, F.
Virulence of Agrobacterium tumefaciens requires phosphatidylcholine in the bacterial membrane
Mol. Microbiol.
62
906-915
2006
BRENDA: Agrobacterium tumefaciens, Agrobacterium tumefaciens C58 / ATCC 33970
Textmining: bacterium, Bacteria, Agrobacterium
Wuenschmann, J.; Beck, A.; Meyer, L.; Letzel, T.; Grill, E.; Lendzian, K.J.
Phytochelatins are synthesized by two vacuolar serine carboxypeptidases in Saccharomyces cerevisiae
FEBS Lett.
581
1681-1687
2007
Saccharomyces cerevisiae
Conover, G.M.; Martinez-Morales, F.; Heidtman, M.I.; Luo, Z.Q.; Tang, M.; Chen, C.; Geiger, O.; Isberg, R.R.
Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants
Cell. Microbiol.
10
514-528
2008
BRENDA: Legionella pneumophila
Textmining: bacterium
Solis-Oviedo, R.L.; Martinez-Morales, F.; Geiger, O.; Sohlenkamp, C.
Functional and topological analysis of phosphatidylcholine synthase from Sinorhizobium meliloti
Biochim. Biophys. Acta
1821
573-581
2012
BRENDA: Sinorhizobium meliloti (Q9KJY8), Sinorhizobium meliloti
Textmining: Bacteria, eukaryota
Geiger, O.; Lopez-Lara, I.M.; Sohlenkamp, C.
Phosphatidylcholine biosynthesis and function in bacteria
Biochim. Biophys. Acta
1831
503-513
2013
BRENDA: Agrobacterium tumefaciens, Bacillus subtilis, Brucella abortus, Brucella melitensis, Escherichia coli, Pseudomonas aeruginosa (Q9HXE9), Pseudomonas putida, Pseudomonas putida KT 2240, Sinorhizobium meliloti
Textmining: Bacteria, eukaryota
He, H.; Wu, B.; Xiong, M.; Li, Y.; Wu, W.; Wang, X.
Gene cloning, structural gene and promoter identification, and active assay of the phosphatidylcholine synthase of Pseudomonas sp. strain 593
Can. J. Microbiol.
57
785-794
2011
BRENDA: Pseudomonas sp. (E9NR86), Pseudomonas sp., Pseudomonas sp. 593 (E9NR86)
Textmining: Pseudomonas, bacterium, Escherichia coli BL21 (DE3) pLysS, Escherichia coli
Palusinska-Szysz, M.; Janczarek, M.; Kalitynski, R.; Dawidowicz, A.L.; Russa, R.
Legionella bozemanae synthesizes phosphatidylcholine from exogenous choline
Microbiol. Res.
166
87-98
2011
BRENDA: Legionella bozemanae (D5KX81), Legionella bozemanae, Legionella bozemanae ATCC 33217 (D5KX81)
Textmining: Bacteria, eukaryota, Legionella pneumophila, Legionella drancourtii
Boeris, P.S.; Lucchesi, G.I.
The phosphatidylcholine synthase of Pseudomonas putida A ATCC 12633 is responsible for the synthesis of phosphatidylcholine, which acts as a temporary reservoir for Al3+
Microbiology
158
1249-1257
2012
Pseudomonas putida, Pseudomonas putida A ATCC 12633
Aktas, M.; Koester, S.; Kizilirmak, S.; Casanova, J.C.; Betz, H.; Fritz, C.; Moser, R.; Yildiz, O.e.; Narberhaus, F.
Enzymatic properties and substrate specificity of a bacterial phosphatidylcholine synthase
FEBS J.
281
3523-3541
2014
BRENDA: Agrobacterium tumefaciens (A9CIM3), Agrobacterium tumefaciens, Agrobacterium tumefaciens C58 / ATCC 33970 (A9CIM3)
Textmining: Bacteria, plant
Palusinska-Szysz, M.; Szuster-Ciesielska, A.; Kania, M.; Janczarek, M.; Chmiel, E.; Danikiewicz, W.
Legionella dumoffii utilizes exogenous choline for phosphatidylcholine synthesis
Int. J. Mol. Sci.
15
8256-8279
2014
BRENDA: Fluoribacter dumoffii (S4X5L9), Fluoribacter dumoffii
Textmining: Bacteria, Legionella bozemanae, Legionella longbeachae, Legionella drancourtii, eukaryota
Chen, J; Wang, X; Zhang, W; Zhang, S; Zhao, FJ
Protein phosphatase 2A alleviates cadmium toxicity by modulating ethylene production in Arabidopsis thaliana.
Plant Cell Environ
2020
Arabidopsis thaliana
Xiong, M; Wu, B; He, H; Li, Y; Wang, X
[Soil bacterium Pseudomonas sp. 593 synthesizes phosphatidylcholine via phosphatidylcholine synthase pathway].
Wei Sheng Wu Xue Bao
51
747-55
2011
Bacteria, bacterium, Pseudomonas sp.
Aragn-Aranda, B; Palacios-Chaves, L; Salvador-Bescs, M; de Miguel, MJ; Muoz, PM; Vences-Guzmn, M; Ziga-Ripa, A; Lzaro-Antn, L; Sohlenkamp, C; Moriyn, I; Iriarte, M; Conde-lvarez, R
The Phospholipid N-Methyltransferase and Phosphatidylcholine Synthase Pathways and the ChoXWV Choline Uptake System Involved in Phosphatidylcholine Synthesis Are Widely Conserved in Most, but Not All Brucella Species.
Front Microbiol
12
614243
2021
Brucella, Bacteria
de Rudder, KE; López-Lara, IM; Geiger, O
Inactivation of the gene for phospholipid N-methyltransferase in Sinorhizobium meliloti: phosphatidylcholine is required for normal growth.
Mol Microbiol
37
763-72
2000
Sinorhizobium
Ha, SB; Smith, AP; Howden, R; Dietrich, WM; Bugg, S; O'Connell, MJ; Goldsbrough, PB; Cobbett, CS
Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe.
Plant Cell
11
1153-64
1999
Arabidopsis, Schizosaccharomyces pombe, Escherichia coli
Tsuji, N; Nishikori, S; Iwabe, O; Shiraki, K; Miyasaka, H; Takagi, M; Hirata, K; Miyamoto, K
Characterization of phytochelatin synthase-like protein encoded by alr0975 from a prokaryote, Nostoc sp. PCC 7120.
Biochem Biophys Res Commun
315
751-5
2004
Bacteria
Konishi, T; Matsumoto, S; Tsuruwaka, Y; Shiraki, K; Hirata, K; Tamaru, Y; Takagi, M
Enhancing the tolerance of zebrafish (Danio rerio) to heavy metal toxicity by the expression of plant phytochelatin synthase.
J Biotechnol
122
316-25
2006
Danio rerio, Arabidopsis thaliana
Matsuura, H; Yamamoto, Y; Muraoka, M; Akaishi, K; Hori, Y; Uemura, K; Tsuji, N; Harada, K; Hirata, K; Bamba, T; Miyasaka, H; Kuroda, K; Ueda, M
Development of surface-engineered yeast cells displaying phytochelatin synthase and their application to cadmium biosensors by the combined use of pyrene-excimer fluorescence.
Biotechnol Prog
2013
Saccharomyces cerevisiae, Arabidopsis
Yong, X; Chen, Y; Liu, W; Xu, L; Zhou, J; Wang, S; Chen, P; Ouyang, P; Zheng, T
Enhanced cadmium resistance and accumulation in Pseudomonas putida KT2440 expressing the phytochelatin synthase gene of Schizosaccharomyces pombe.
Lett Appl Microbiol
58
255-61
2014
Bacteria, plant
Shri, M; Dave, R; Diwedi, S; Shukla, D; Kesari, R; Tripathi, RD; Trivedi, PK; Chakrabarty, D
Heterologous expression of Ceratophyllum demersum phytochelatin synthase, CdPCS1, in rice leads to lower arsenic accumulation in grain.
Sci Rep
4
5784
2014
plant
Zhao, C; Xu, J; Li, Q; Li, S; Wang, P; Xiang, F
Cloning and characterization of a Phragmites australis phytochelatin synthase (PaPCS) and achieving Cd tolerance in tall fescue.
PLoS One
9
e103771
2014
Saccharomyces cerevisiae
Gupton-Campolongo, T; Damasceno, LM; Hay, AG; Ahner, BA
Characterization of a High Affinity Phytochelatin Synthase from The Cd-Utilizing Marine Diatom Thalassiosira pseudonana.
J Phycol
49
32-40
2013
Nitzschia alba, Thalassiosira pseudonana, Arabidopsis thaliana, Thalassiosira
Uraguchi, S; Sone, Y; Ohta, Y; Ohkama-Ohtsu, N; Hofmann, C; Hess, N; Nakamura, R; Takanezawa, Y; Clemens, S; Kiyono, M
Identification of C-terminal Regions in Arabidopsis thaliana Phytochelatin Synthase 1 Specifically Involved in Activation by Arsenite.
Plant Cell Physiol
59
500-509
2018
Arabidopsis
Yamazaki, S; Ueda, Y; Mukai, A; Ochiai, K; Matoh, T
Rice phytochelatin synthases OsPCS1 and OsPCS2 make different contributions to cadmium and arsenic tolerance.
Plant Direct
2
e00034
2018
Oryza sativa
He Z;Li J;Zhang H;Ma M
Different effects of calcium and lanthanum on the expression of phytochelatin synthase gene and cadmium absorption in Lactuca sativa.
Plant science : an international journal of experimental plant biology
168
309-318
2005
plant
Di, DD; Jiang, H; Tian, LL; Kang, JL; Zhang, W; Yi, XP; Ye, F; Zhong, Q; Ni, B; He, YY; Xia, L; Yu, Y; Cui, BY; Mao, X; Fan, WX
Comparative genomic analysis between newly sequenced Brucella suis Vaccine Strain S2 and the Virulent Brucella suis Strain 1330.
BMC Genomics
17
741
0
Bacteria, Brucella
Kang, SH; Singh, S; Kim, JY; Lee, W; Mulchandani, A; Chen, W
Bacteria metabolically engineered for enhanced phytochelatin production and cadmium accumulation.
Appl Environ Microbiol
73
6317-20
2007
Escherichia coli, Schizosaccharomyces pombe
Vasilopoulos, G; Moser, R; Petersen, J; Aktas, M; Narberhaus, F
Promiscuous phospholipid biosynthesis enzymes in the plant pathogen Pseudomonas syringae.
Biochim Biophys Acta Mol Cell Biol Lipids
1866
158926
2021
Bacteria
Vatamaniuk, OK; Bucher, EA; Sundaram, MV; Rea, PA
CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.
J Biol Chem
280
23684-90
2005
Caenorhabditis elegans, Schizosaccharomyces pombe, plant
Inouhe, M; Ito, R; Ito, S; Sasada, N; Tohoyama, H; Joho, M
Azuki bean cells are hypersensitive to cadmium and do not synthesize phytochelatins.
Plant Physiol
123
1029-36
2000
Vigna angularis
López-Lara, IM; Geiger, O
Novel pathway for phosphatidylcholine biosynthesis in bacteria associated with eukaryotes.
J Biotechnol
91
211-21
2001
Bacteria, eukaryota, Borreliella burgdorferi, Legionella
Takagi, M; Satofuka, H; Amano, S; Mizuno, H; Eguchi, Y; Hirata, K; Miyamoto, K; Fukui, K; Imanaka, T
Cellular toxicity of cadmium ions and their detoxification by heavy metal-specific plant peptides, phytochelatins, expressed in Mammalian cells.
J Biochem (Tokyo)
131
233-9
2002
Arabidopsis thaliana
Sohlenkamp, C; López-Lara, IM; Geiger, O
Biosynthesis of phosphatidylcholine in bacteria.
Prog Lipid Res
42
115-62
2003
Bacteria, Borreliella burgdorferi, Pseudomonas aeruginosa, Legionella, Brucella melitensis, Mesorhizobium
López-Lara, IM; Sohlenkamp, C; Geiger, O
Membrane lipids in plant-associated bacteria: their biosyntheses and possible functions.
Mol Plant Microbe Interact
16
567-79
2003
Medicago, Sinorhizobium meliloti
Sohlenkamp, C; de Rudder, KE; Geiger, O
Phosphatidylethanolamine is not essential for growth of Sinorhizobium meliloti on complex culture media.
J Bacteriol
186
1667-77
2004
Sinorhizobium meliloti
Hirata, K; Tsujimoto, Y; Namba, T; Ohta, T; Hirayanagi, N; Miyasaka, H; Zenk, MH; Miyamoto, K
Strong induction of phytochelatin synthesis by zinc in marine green alga, Dunaliella tertiolecta.
J Biosci Bioeng
92
24-9
2001
Dunaliella tertiolecta, Embryophyta
Comerci, DJ; Altabe, S; de Mendoza, D; Ugalde, RA
Brucella abortus Synthesizes Phosphatidylcholine from Choline Provided by the Host.
J Bacteriol
188
1929-34
2006
Brucella, Brucella abortus, Bacteria, Escherichia coli, eukaryota, Mus sp., Brucella abortus 2308, Transformation
Chen, A; Komives, EA; Schroeder, JI
An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis.
Plant Physiol
141
108-20
2006
Arabidopsis, Triticum aestivum
Boeris, PS; Liffourrena, AS; Salvano, MA; Lucchesi, GI
Physiological role of phosphatidylcholine in the Pseudomonas putida A ATCC 12633 response to tetradecyltrimethylammonium bromide and aluminium.
Lett Appl Microbiol
49
491-6
2009
Pseudomonas putida A ATCC 12633, Bacteria, Pseudomonas putida
Chen, F; Zhao, Q; Cai, X; Lv, L; Lin, W; Yu, X; Li, C; Li, Y; Xiong, M; Wang, XG
Phosphatidylcholine in membrane of Escherichia coli changes bacterial antigenicity.
Can J Microbiol
55
1328-34
2009
Escherichia coli, Mus sp., Oryctolagus cuniculus, Electron
Medeot, DB; Sohlenkamp, C; Dardanelli, MS; Geiger, O; de Lema, MG; López-Lara, IM
Phosphatidylcholine levels of peanut-nodulating Bradyrhizobium sp. SEMIA 6144 affect cell size and motility.
FEMS Microbiol Lett
303
123-31
2010
Bradyrhizobium sp., Semia, Bacteria, Bradyrhizobium, Bradyrhizobium japonicum, eukaryota, Arachis hypogaea, Glycine max, Bradyrhizobium diazoefficiens USDA 110, Bradyrhizobium diazoefficiens, plant
Aktas, M; Wessel, M; Hacker, S; Klsener, S; Gleichenhagen, J; Narberhaus, F
Phosphatidylcholine biosynthesis and its significance in bacteria interacting with eukaryotic cells.
Eur J Cell Biol
2010
Bacteria
Aktas, M; Jost, KA; Fritz, C; Narberhaus, F
Choline uptake in Agrobacterium tumefaciens by the high-affinity ChoXWV transporter.
J Bacteriol
2011
Agrobacterium tumefaciens, Transformation, plant
Xiong, M; Long, D; He, H; Li, Y; Li, Y; Wang, X
Phosphatidylcholine synthesis is essential for HrpZ harpin secretion in plant pathogenic Pseudomonas syringae and non-pathogenic Pseudomonas sp. 593.
Microbiol Res
2013
Pseudomonas sp., Pseudomonas syringae, plant, Pseudomonas, Pseudomonas syringae pv. syringae, Glycine max, Nicotiana tabacum, bacterium
Palusi?ska-Szysz, M; Szuster-Ciesielska, A; Janczarek, M; Wdowiak-Wrbel, S; Schiller, J; Reszczy?ska, E; Gruszecki, WI; Fuchs, B
Genetic diversity of Legionella pcs and pmtA genes and the effect of utilization of choline by Legionella spp. on induction of proinflammatory cytokines.
Pathog Dis
77
2019
Legionella
Nilsson, I; Lee, SY; Sawyer, WS; Baxter Rath, CM; Lapointe, G; Six, D
Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes.
J Lipid Res
2020
Escherichia coli
Romanyuk, ND; Rigden, DJ; Vatamaniuk, OK; Lang, A; Cahoon, RE; Jez, JM; Rea, PA
Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase.
Plant Physiol
141
858-69
2006
Nostoc sp.
Wojas, S; Clemens, S; Skłodowska, A; Maria Antosiewicz, D
Arsenic response of AtPCS1- and CePCS-expressing plants - Effects of external As(V) concentration on As-accumulation pattern and NPT metabolism.
J Plant Physiol
2009
Nicotiana tabacum
Zenk, MH
Heavy metal detoxification in higher plants--a review.
Gene
179
21-30
1996
Embryophyta, Arabidopsis thaliana
Cobbett, C; Goldsbrough, P
Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis.
Annu Rev Plant Biol
53
159-82
2002
Arabidopsis, plant
Hirata, K; Tsuji, N; Miyamoto, K
Biosynthetic regulation of phytochelatins, heavy metal-binding peptides.
J Biosci Bioeng
100
593-9
2005
Bacteria, Embryophyta, Schizosaccharomyces pombe, plant
Tennstedt, P; Peisker, D; Böttcher, C; Trampczynska, A; Clemens, S
Phytochelatin synthesis is essential for the detoxification of excess zinc and contributes significantly to the accumulation of zinc.
Plant Physiol
149
938-48
2009
Arabidopsis, Schizosaccharomyces pombe, Saccharomyces cerevisiae, plant
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