Cloned (Comment) | Organism |
---|---|
from plasmid pGC41 in pGC36 for functional complementation in bacterial mutants lacking endogenous PcsA | Legionella pneumophila |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-diacylglycerol + choline | Legionella pneumophila | phosphatidylcholine synthesis important for functionality of Dot/Icm translocator (formation of replicative vacuole), binding to macrophages, sufficient level of flagellin protein (linked to bacterial cytotoxicity, cellular adhesion) | CMP + phosphatidylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Legionella pneumophila | - |
Philadelphia-1 strain Lp02 derivatives | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-diacylglycerol + choline | phosphatidylcholine synthesis important for functionality of Dot/Icm translocator (formation of replicative vacuole), binding to macrophages, sufficient level of flagellin protein (linked to bacterial cytotoxicity, cellular adhesion) | Legionella pneumophila | CMP + phosphatidylcholine | - |
? | |
CDP-diacylglycerol + choline | overexpression of PcsA complements low phosphatidylcholine levels in membrane of mutant strain lacking PcsA or lacking both PcsA and PmtA (phospholipid N-methyltransferase) | Legionella pneumophila | CMP + phosphatidylcholine | lipid analysis by thin-layer chromatography | ? |
Synonyms | Comment | Organism |
---|---|---|
PcsA | - |
Legionella pneumophila |
PcsA | lidK/pcsA gene product | Legionella pneumophila |
phosphatidylcholine synthase | - |
Legionella pneumophila |