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Information on EC 2.7.4.6 - nucleoside-diphosphate kinase and Organism(s) Acanthamoeba polyphaga mimivirus and UniProt Accession Q5UQL3

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IUBMB Comments
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
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This record set is specific for:
Acanthamoeba polyphaga mimivirus
UNIPROT: Q5UQL3
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The taxonomic range for the selected organisms is: Acanthamoeba polyphaga mimivirus
The enzyme appears in selected viruses and cellular organisms
Synonyms
nm23-h1, nucleoside diphosphate kinase, ndp kinase, nm23-h2, ndpk-b, ndpk2, nucleoside diphosphokinase, ndk-1, nucleoside-diphosphate kinase, nucleoside diphosphate kinase a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleoside diphosphate kinase
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kinase, nucleoside diphosphate (phosphorylating)
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-
-
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NDK
-
-
-
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nucleoside 5'-diphosphate kinase
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-
-
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nucleoside diphosphate (UDP) kinase
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-
-
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nucleoside diphosphokinase
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-
-
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nucleotide phosphate kinase
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-
-
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UDP kinase
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-
-
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uridine diphosphate kinase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:nucleoside-diphosphate phosphotransferase
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-51-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + CDP
ADP + CTP
show the reaction diagram
-
-
-
?
ATP + dADP
ADP + dATP
show the reaction diagram
-
-
-
?
ATP + dCDP
ADP + dCTP
show the reaction diagram
-
-
-
?
ATP + dGDP
ADP + dGTP
show the reaction diagram
-
-
-
?
ATP + dTDP
ADP + dTTP
show the reaction diagram
-
-
-
?
ATP + dUDP
ADP + dUTP
show the reaction diagram
-
-
-
?
ATP + NDP
ADP + NTP
show the reaction diagram
-
-
-
?
ATP + UDP
ADP + UTP
show the reaction diagram
-
-
-
?
ADP + CTP
ATP + CDP
show the reaction diagram
-
-
-
-
?
ADP + dCTP
ATP + dCDP
show the reaction diagram
-
-
-
-
?
ADP + dTTP
ATP + dTDP
show the reaction diagram
-
-
-
-
?
ADP + dUTP
ATP + dUDP
show the reaction diagram
-
-
-
-
?
ADP + GTP
ATP + GDP
show the reaction diagram
-
-
-
-
?
ADP + UTP
ATP + UDP
show the reaction diagram
-
-
-
-
?
ATP + CDP
ADP + CTP
show the reaction diagram
-
-
-
-
?
ATP + dCDP
ADP + dCTP
show the reaction diagram
-
-
-
-
?
ATP + dTDP
ADP + dTTP
show the reaction diagram
-
-
-
-
?
ATP + dUDP
ADP + dUTP
show the reaction diagram
-
-
-
-
?
ATP + GDP
ADP + GTP
show the reaction diagram
-
-
-
-
?
ATP + UDP
ADP + UTP
show the reaction diagram
-
-
-
-
?
dGDP + ATP
dGTP + ADP
show the reaction diagram
-
-
-
-
?
dGTP + ADP
dGDP + ATP
show the reaction diagram
-
-
-
-
?
GTP + ADP
GDP + ATP
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + NDP
ADP + NTP
show the reaction diagram
-
-
-
?
additional information
?
-
-
role of enzyme in dUTP detoxification to compensate for the absence of a dUTPase in Mimivirus
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dCDP
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minimal inhibitory concentration 0.010 to 0.050mM
dTDP
-
minimal inhibitory concentration 0.001 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001 - 0.03
dTDP
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NDK_MIMIV
137
0
15750
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
112000
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
x-ray crystallography
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with nucleotides, vapor diffusion method, using 40-45% (v/v) 2-methyl-2,4-pentane-d12-diol in 0.1 M HEPES (pH 7.5) or 0.1 M MOPS (pH 7.4)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
HiTrap Ni2+ chelating column chromatography, gel filtration
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jeudy, S.; Claverie, J.M.; Abergel, C.
The nucleoside diphosphate kinase from mimivirus: a peculiar affinity for deoxypyrimidine nucleotides
J. Bioenerg. Biomembr.
38
247-254
2006
Acanthamoeba polyphaga Mimivirus
Manually annotated by BRENDA team
Jeudy, S.; Lartigue, A.; Claverie, J.M.; Abergel, C.
Dissecting the unique nucleotide specificity of mimivirus nucleoside diphosphate kinase
J. Virol.
83
7142-7150
2009
Acanthamoeba polyphaga Mimivirus (Q5UQL3), Acanthamoeba polyphaga Mimivirus
Manually annotated by BRENDA team